Tamirci Mevhibe, Aydin Volkan, Soyalan Mertdogan, Akici Narin, Goren Mehmet Zafer, Akici Ahmet
Department of Pharmacology, European University of Lefke Faculty of Pharmacy, Lefke, Northern Cyprus.
Department of Medical Pharmacology, Marmara University Faculty of Medicine, Istanbul, Turkey.
North Clin Istanb. 2020 Nov 25;8(1):49-56. doi: 10.14744/nci.2020.27003. eCollection 2021.
Drug utilization habits of the pregnant are a critical aspect of rational use of the medicine (RUM). This study aimed to analyze the RUM related attitudes and the behaviors of women during their pregnancies.
The data were collected between May 2016-October 2016 by conducting surveys to 71 pregnant women admitted to the private and governmental hospitals in five districts of Northern Cyprus. The sociodemographic characteristics of the pregnant as well as their attitudes and behaviors concerning drug use were evaluated.
The mean age and the gestational week of the patients was 29.7±4.3 years and 25.7±11.2 weeks, respectively. Planned pregnancies constituted 71.8% of all. The percentage of patients with an unplanned pregnancies who were using drugs at the time of the survey (25.0%) was lower than that in those with planned pregnancies (49.0%, p<0.05). Almost two-thirds (66.2%) of the women were exposed to a drug during pregnancy, mostly for "vitamin/mineral prophylaxis" (38.3%) and agents controlling nausea/vomiting (19.1%). Two out of eleven women (18.2%) were using folic acid when they learned about their pregnancy. One of the drugs used for the chronic disorder in the third trimester was acetylsalicylic acid (11.1%), a category D drug in this setting. Most of the patients stated that they frequently read the instructions (60.9%), "often" paying attention to side effects (56.5%). Considering some of the habits related to drug use, 8.7% and 10.9% of pregnant women declared that they sometimes "did not follow the instructions" and "dosage/duration of the drug usage", respectively. Seven patients (15.2%) declared that they did not consider side effects on the medication guide while more than half (56.5%) did it "often". Near one in five (19.6%) of the pregnant women stated that they hesitated about the drug usage due to teratogenicity risks.
Our study highlights the drug utilization attitudes and behaviors of pregnant women during pregnancy in Northern Cyprus, indicating several shortcomings, including insufficient prenatal folic acid use, occasional use of risky drugs, and unsatisfactory medication guide handling. Available findings underline the necessity of education not only for patients but also for healthcare providers to disseminate RUM in pregnancy.
孕妇的药物使用习惯是合理用药（RUM）的一个关键方面。本研究旨在分析孕妇在孕期与合理用药相关的态度和行为。
2016年5月至2016年10月期间，对北塞浦路斯五个地区私立和公立医院收治的71名孕妇进行调查，收集数据。评估了孕妇的社会人口学特征以及她们在药物使用方面的态度和行为。
患者的平均年龄和孕周分别为29.7±4.3岁和25.7±11.2周。计划内怀孕占所有怀孕的71.8%。调查时正在用药的意外怀孕患者比例（25.0%）低于计划内怀孕患者（49.0%，p<0.05）。近三分之二（66.2%）的女性在孕期接触过药物，主要用于“维生素/矿物质预防”（38.3%）和控制恶心/呕吐的药物（19.1%）。11名女性中有2名（18.2%）在得知自己怀孕时正在服用叶酸。孕晚期用于慢性疾病的药物之一是乙酰水杨酸（11.1%），在此情况下属于D类药物。大多数患者表示他们经常阅读说明书（60.9%），“经常”关注副作用（56.5%）。考虑到一些与药物使用相关的习惯，8.7%和10.9%的孕妇分别表示她们有时“不遵循说明书”和“药物使用剂量/持续时间”。7名患者（15.2%）表示她们在用药指南中没有考虑副作用，而超过一半（56.5%）的患者“经常”考虑。近五分之一（19.6%）的孕妇表示由于致畸风险，她们在用药方面犹豫不决。
我们的研究突出了北塞浦路斯孕妇在孕期的药物使用态度和行为，表明存在一些不足之处，包括产前叶酸使用不足、偶尔使用有风险的药物以及对用药指南的处理不尽人意。现有研究结果强调不仅有必要对患者进行教育，也有必要对医疗保健提供者进行教育，以在孕期传播合理用药知识。
