Radhakishun F S, van Ree J M, Westerink B H
Department of Medicinal Chemistry, State University Groningen, The Netherlands.
Neurosci Lett. 1988 Mar 10;85(3):351-6. doi: 10.1016/0304-3940(88)90591-5.
This study examined the effect of scheduled eating on the in vivo release of dopamine (DA) in the nucleus accumbens of rats that were maintained on a food deprivation schedule. DA release was measured by means of a fully automated on-line brain dialysis system. The initiation of eating increased the release of DA, which remained elevated during the entire eating period. Termination of eating caused a gradual decrease of the release of DA to basal values. Increased motor activities did not change the release of DA. These results indicate a link between eating and DA release and demonstrate the suitability of on-line brain dialysis for behavioural experiments.
