Pope Jason E, Fishman Michael, Chakravarthy Krishnan, Hanes Michael, Gerling Michael, Heros Robert, Falowski Steven, Shah Jay, Orhurhu Vwaire, Urits Ivan, Deer Timothy R
Evolve Restorative Center, Santa Rosa, CA, USA.
Main Line Health, Exton, PA, USA.
Pain Ther. 2021 Jun;10(1):539-550. doi: 10.1007/s40122-021-00238-z. Epub 2021 Feb 23.
Multidisciplinary patient-reported outcomes are a critical part of assessing patients to better understand their well-being during treatment. The use of multidisciplinary patient-reported outcomes is recommended in many areas of medicine. The Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29) has been utilized as a common measurement language across universally relevant domains, including pain, mood, sleep, social participation, and function.
Retrospective analysis of prospectively collected data was performed. Subjects were identified and consecutively enrolled upon entry into chronic pain centers across 24 sites in the United States. The PROMIS-29 v2.1 and the numerical rating scale (NRS) were recorded. The pain impact score and the Health Utilities Index Mark 3 (HUI-3) were calculated. Statistical differences were assessed between genders and among age groups comprising subjects less than 40, 41-60, 61-80, and over 80 years of age.
A total of 19,546 patients were assessed over the enrollment period from 2018 to 2020. The PROMIS-29 v2.1 was evaluated across the seven domains, along with the numerical rating sale (NRS). The mean scores of the population for PROMIS SF v1.0 Pain Interference 4a, PROMIS SF v1.0 Sleep Disturbance 4a, PROMIS SF v1.0 Fatigue 4a, PROMIS SF v1.0 Anxiety 4a, PROMIS SF V1.0 Depression 4a, PROMIS SF v2.0 Ability to Participate in Social Roles and Activities 4a, and PROMIS SF v1.0 Physical Function 4a, measuring pain interference, sleep disturbance, fatigue, anxiety, depression, social participation, and physical function, were 64.61, 57.19, 58.50, 53.94, 54.45, 40.06, and 36.23, respectively. Pain intensity was 6.38 on an 11-point NRS scale. The pain impact score (PIS) and health utilities index mark 3 (HUI-3) scores, calculated across the designated age groups, were 33.19 and 0.67, respectively. Statistical differences were observed for the domains of sleep disturbance and physical function for age groups less than 40 and greater than 80 years of age.
This data set is the first published normative data set describing the PROMIS-29 assessment in the chronic pain population. The patient population is more homogeneous than expected, and females were found to have higher levels of dysfunction.
多学科患者报告结局是评估患者以更好地了解其治疗期间健康状况的关键部分。多学科患者报告结局的使用在医学的许多领域都得到了推荐。患者报告结局测量信息系统29项（PROMIS - 29）已被用作通用的测量语言，涵盖了普遍相关的领域，包括疼痛、情绪、睡眠、社会参与和功能。
对前瞻性收集的数据进行回顾性分析。在美国24个地点的慢性疼痛中心，对进入中心的受试者进行识别并连续纳入研究。记录PROMIS - 29 v2.1和数字评分量表（NRS）。计算疼痛影响评分和健康效用指数Mark 3（HUI - 3）。评估不同性别以及年龄组（包括小于40岁、41 - 60岁、61 - 80岁和80岁以上）之间的统计差异。
在2018年至2020年的入组期间，共评估了19546例患者。对PROMIS - 29 v2.1在七个领域进行了评估，并同时评估了数字评分量表（NRS）。PROMIS SF v1.0疼痛干扰4a、PROMIS SF v1.0睡眠障碍4a、PROMIS SF v1.0疲劳4a、PROMIS SF v1.0焦虑4a、PROMIS SF v1.0抑郁4a、PROMIS SF v2.0参与社会角色和活动的能力4a以及PROMIS SF v1.0身体功能4a（分别测量疼痛干扰、睡眠障碍、疲劳、焦虑、抑郁、社会参与和身体功能）的总体平均得分分别为64.61、57.19、58.50、53.94、54.45、40.06和36.23。在11分制的NRS量表上，疼痛强度为6.38。在指定年龄组中计算的疼痛影响评分（PIS）和健康效用指数Mark 3（HUI - 3）得分分别为33.19和0.67。在小于40岁和大于80岁的年龄组中，观察到睡眠障碍和身体功能领域存在统计差异。
该数据集是首个发表的描述慢性疼痛人群中PROMIS - 29评估的规范数据集。患者群体比预期的更具同质性，并且发现女性的功能障碍水平更高。
