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经验证的自动化血管内超声衍生钙化评分的预后价值

The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score.

作者信息

Neleman Tara, Liu Shengnan, Tovar Forero Maria N, Hartman Eline M J, Ligthart Jurgen M R, Witberg Karen T, Cummins Paul, Zijlstra Felix, Van Mieghem Nicolas M, Boersma Eric, van Soest Gijs, Daemen Joost

机构信息

Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.

出版信息

J Cardiovasc Transl Res. 2021 Oct;14(5):992-1000. doi: 10.1007/s12265-021-10103-1. Epub 2021 Feb 23.

DOI:10.1007/s12265-021-10103-1
PMID:33624259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8575752/
Abstract

BACKGROUND

Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE).

METHODS

We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE).

RESULTS

In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05-2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04-1.41, p value = 0.014, respectively).

CONCLUSIONS

The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE.

摘要

背景

冠状动脉钙化与心血管事件相关。我们开发并验证了一种算法，用于在血管内超声（IVUS）上自动量化冠状动脉钙化。我们旨在评估血管内超声钙化评分（ICS）对以患者为导向的复合终点（POCE）的预后价值。

方法

我们纳入了接受冠状动脉造影及术前IVUS成像的患者。计算每位患者的ICS。主要终点是全因死亡、中风、心肌梗死和血运重建的复合终点（POCE）。

结果

在一个408例患者的队列中，ICS中位数为85。在6年随访中，ICS≥85以及ICS增加100个单位均增加了POCE风险（调整后风险比[aHR]分别为1.51，95%置信区间[CI] 1.05 - 2.17，p值 = 0.026；以及aHR 1.21，95%CI 1.04 - 1.41，p值 = 0.014）。

结论

通过源自常规IVUS回撤的经过验证的自动化算法计算得出的ICS，与POCE的长期风险密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/1d62fa30a7ae/12265_2021_10103_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/15303e41fa72/12265_2021_10103_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/703bc1a6f922/12265_2021_10103_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/1d62fa30a7ae/12265_2021_10103_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/15303e41fa72/12265_2021_10103_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/703bc1a6f922/12265_2021_10103_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50c/8575752/1d62fa30a7ae/12265_2021_10103_Fig3_HTML.jpg

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