在经谷氨酸钠预处理的大鼠中进行垂体切除术可抑制异相睡眠反弹。

Hypophysectomy in monosodium glutamate-pretreated rats suppresses paradoxical sleep rebound.

作者信息

Zhang J X, Valatx J L, Jouvet M

机构信息

Laboratoire de Médecine Expérimentale, INSERM U52, C.N.R.S. UA1195, Université Claude Bernard, Lyon France.

出版信息

Neurosci Lett. 1988 Mar 21;86(1):94-8. doi: 10.1016/0304-3940(88)90189-9.

DOI:10.1016/0304-3940(88)90189-9

PMID:3362433

Abstract

Control untreated and pretreated female rats at birth with 10 injections of monosodium glutamate (MSG, 4 mg/g b. wt.) were hypophysectomized (HYPX) at 45-60 days of age and their sleep-waking cycle continuously registered. In control rats, hypophysectomy was followed by a 35.7% decrease in paradoxical sleep (PS) duration while it has no effect on the sleep of MSG-treated rats. After 24 h of PS deprivation, there was a normal immediate rebound of PS in the control HYPX and MSG rats while there was no significant rebound in the HYPX-MSG-treated rats. It is concluded that neuropeptides from arcuate nucleus and hypophysis are involved in a PS rebound mechanism.

摘要

出生时用10次谷氨酸单钠（MSG，4mg/g体重）注射处理的未处理和预处理的雌性大鼠在45-60日龄时进行垂体切除（HYPX），并持续记录它们的睡眠-觉醒周期。在对照大鼠中，垂体切除后异相睡眠（PS）持续时间减少了35.7%，而对MSG处理的大鼠的睡眠没有影响。在PS剥夺24小时后，对照HYPX和MSG大鼠的PS有正常的即时反弹，而HYPX-MSG处理的大鼠没有明显的反弹。结论是，来自弓状核和垂体的神经肽参与了PS反弹机制。