Zhang J X, Valatx J L, Jouvet M
Laboratoire de Médecine Expérimentale, INSERM U52, CNRS UA1195, Université Claude Bernard, Lyon, France.
Brain Res Bull. 1988 Dec;21(6):897-903. doi: 10.1016/0361-9230(88)90024-x.
Monosodium Glutamate (MSG), known to induce neuronal cell degeneration of the arcuate nucleus of the hypothalamus, was subcutaneously injected (4 mg/g body wt.) at postnatal days 1 to 5 or 1 to 10 in female rats. Hypophysectomy was performed at 45-60 days of age. Sleep parameters were continuously recorded for at least 7 days. Results indicated that hypophysectomized (HYPX) NaCl-treated rats showed an increase of Slow Wave Sleep (SWS) (+29.6%) and a decrease of Paradoxical Sleep (PS) (-36.7%) durations. In MSG-treated rats, hypophysectomy did not alter SWS durations but it increased PS durations as MSG dosing increased. It was concluded that arcuate nucleus neurons seemed to be not critically involved in sleep production mechanisms.
已知味精（MSG）可诱导下丘脑弓状核的神经元细胞变性，在出生后第1至5天或第1至10天对雌性大鼠皮下注射（4毫克/克体重）。在45至60日龄时进行垂体切除术。连续记录睡眠参数至少7天。结果表明，接受垂体切除（HYPX）并给予氯化钠处理的大鼠慢波睡眠（SWS）时长增加（+29.6%），异相睡眠（PS）时长减少（-36.7%）。在接受味精处理的大鼠中，垂体切除术并未改变SWS时长，但随着味精剂量增加，PS时长增加。得出的结论是，弓状核神经元似乎并非睡眠产生机制的关键参与者。
