Heymsfield Steven B, Smith Brooke, Dahle Jared, Kennedy Samantha, Fearnbach Nicole, Thomas Diana M, Bosy-Westphal Anja, Müller Manfred J
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Integrated Physiology Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Obesity (Silver Spring). 2021 Mar;29(3):500-511. doi: 10.1002/oby.23090.
The basis of heat generated by the human body has been a source of speculation and research for more than 2,000 years. Basal heat production, now usually referred to as resting energy expenditure (REE), is currently recognized as deriving from biochemical reactions at subcellular and cellular levels that are expressed in the energy expended by the body's 78 organs and tissues. These organs and tissues, and the 11 systems to which they belong, influence body size and shape. Connecting these subcellular-/cellular-level reactions to organs and tissues, and then on to body size and shape, provides a comprehensive understanding of individual differences in REE, a contemporary topic of interest in obesity research and clinical practice. This review critically examines these linkages, their association with widely used statistical and physiological REE prediction formulas, and often-unappreciated aspects of measuring basal heat production in humans.
两千多年来，人体产热的基础一直是一个引发猜测和研究的源头。基础产热，现在通常称为静息能量消耗（REE），目前被认为源自亚细胞和细胞水平的生化反应，这些反应表现为身体78个器官和组织所消耗的能量。这些器官和组织以及它们所属的11个系统会影响身体的大小和形状。将这些亚细胞/细胞水平的反应与器官和组织联系起来，进而与身体大小和形状联系起来，能让人全面理解REE的个体差异，这是肥胖研究和临床实践中一个备受关注的当代话题。本综述批判性地审视了这些联系、它们与广泛使用的统计和生理REE预测公式的关联，以及人体基础产热测量中常被忽视的方面。
