通过电荷转移复合物的不对称 [2+2] 光环加成反应合成三环手性醚。
Asymmetric [2+2] photocycloaddition via charge transfer complex for the synthesis of tricyclic chiral ethers.
机构信息
Organic Chemistry Department, Universidad Autónoma de Madrid, Madrid 28049, Spain.
出版信息
Chem Commun (Camb). 2021 Mar 25;57(24):3046-3049. doi: 10.1039/d1cc00035g. Epub 2021 Feb 24.
PMID:33625423
Abstract
The asymmetric synthesis of chiral polycyclic ethers by an intramolecular [2+2] photocycloaddition is described. This process proceeded through a photocatalytically active iminium ion-based charge transfer (CT) complex under visible light irradiation. In this way a stereocontrolled [2+2] photocycloaddition is enabled leading to tricyclic products with good enantiomeric ratios.
摘要
本文描述了通过分子内[2+2]光环加成反应不对称合成手性多环醚。该过程在可见光照射下通过光催化活性的亚胺离子基电荷转移（CT）复合物进行。通过这种方式，可以实现立体控制的[2+2]光环加成反应，得到具有良好对映选择性的三环产物。
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