胰腺保存时间作为胰腺移植后住院时间延长的预测指标。

Pancreas preservation time as a predictor of prolonged hospital stay after pancreas transplantation.

作者信息

Mei Shengmin, Huang Zhichao, Dong Yinlei, Chen Zheng, Xiang Jie, Zhou Jie, Li Zhiwei, Zheng Shusen, Hu Zhenhua

机构信息

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China.

出版信息

J Int Med Res. 2021 Feb;49(2):300060520987059. doi: 10.1177/0300060520987059.

DOI:10.1177/0300060520987059

PMID:33626941

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7925952/

Abstract

OBJECTIVE

Length of hospital stay is a sensitive indicator of short-term prognosis. In this retrospective study, we investigated how pancreas preservation time affects length of hospital stay after pancreas transplantation.

METHODS

Patients receiving pancreas transplantation (1998.7-2018.6) were identified from the Scientific Registry of Transplant Recipients database and grouped according to pancreas preservation time. We analyzed the relationship of pancreas preservation time with graft and patient survival and prolonged length of stay (PLOS; i.e., hospital stay ≥20 days).

RESULTS

We included 18,099 pancreas transplants in the survival analysis. Pancreas preservation time >20 hours had a significantly higher risk of graft failure than 8 to 12 hours. Pancreas preservation time was not significantly associated with patient survival. We included 17,567 pancreas transplants in the analysis for PLOS. Compared with 8 to 12 hours, pancreas preservation time >12 hours had a significantly higher PLOS risk, which increased with increased pancreas preservation time. In simultaneous pancreas-kidney transplantation, we also found that pancreas preservation time was positively associated with PLOS risk with pancreas preservation time >12 hours.

CONCLUSION

Pancreas preservation time is a sensitive predictor of PLOS. Transplant centers should minimize pancreas preservation time to optimize patient outcomes.

摘要

目的

住院时间是短期预后的一个敏感指标。在这项回顾性研究中，我们调查了胰腺保存时间如何影响胰腺移植后的住院时间。

方法

从移植受者科学注册数据库中识别出1998年7月至2018年6月接受胰腺移植的患者，并根据胰腺保存时间进行分组。我们分析了胰腺保存时间与移植物和患者生存率以及延长住院时间（PLOS；即住院时间≥20天）之间的关系。

结果

我们在生存分析中纳入了18099例胰腺移植。胰腺保存时间>20小时的移植物失败风险显著高于8至12小时。胰腺保存时间与患者生存率无显著相关性。我们在PLOS分析中纳入了17567例胰腺移植。与8至12小时相比，胰腺保存时间>12小时的PLOS风险显著更高，且随着胰腺保存时间的增加而增加。在胰肾联合移植中，我们还发现胰腺保存时间>12小时时，胰腺保存时间与PLOS风险呈正相关。