Field H P, Jones R, Walker B E, Kelleher J, Simmons A V
Department of Medicine, St. James's University Hospital, Leeds, UK.
Nutr Cancer. 1988;11(2):83-92. doi: 10.1080/01635588809513974.
Zinc status and the effect of zinc supplementation were assessed in groups of patients with non-Hodgkin's lymphoma and Hodgkin's disease; patients were either untreated or in remission. In the patients in remission, plasma zinc was normal; and whereas 30% of untreated patients had low plasma zinc, the group as a whole did not differ from normal. For mononuclear cell zinc, the range of values in the disease group was far wider than in controls, but there was no significant difference between the means of the groups. Granulocyte zinc was significantly lower in both the groups of patients in remission from non-Hodgkin's lymphoma and Hodgkin's disease compared with the control group. Significant increases were found in the plasma copper, ceruloplasmin, and the copper-to-zinc ratio in several of the patient groups. Plasma zinc increased by 23% with zinc supplementation (50 mg elemental Zn/day), but there was no effect on mononuclear cell or granulocyte zinc. Apart from granulocyte zinc, there is little evidence of zinc deficiency in non-Hodgkin's lymphoma or Hodgkin's disease. However, the presence of depleted granulocyte zinc levels could modify the immune function of this cell population.
对非霍奇金淋巴瘤和霍奇金病患者组的锌状态及补锌效果进行了评估；患者要么未经治疗，要么处于缓解期。处于缓解期的患者血浆锌正常；30%未经治疗的患者血浆锌水平较低，但总体组与正常组无差异。对于单核细胞锌，疾病组的值范围比对照组宽得多，但两组的均值无显著差异。与对照组相比，非霍奇金淋巴瘤和霍奇金病缓解期患者组的粒细胞锌均显著降低。在几个患者组中发现血浆铜、铜蓝蛋白和铜锌比显著升高。补锌（每天50毫克元素锌）后血浆锌增加了23%，但对单核细胞或粒细胞锌没有影响。除了粒细胞锌外，几乎没有证据表明非霍奇金淋巴瘤或霍奇金病存在锌缺乏。然而，粒细胞锌水平降低可能会改变该细胞群体的免疫功能。
