韩国B细胞非霍奇金淋巴瘤患者中乙肝病毒感染的高患病率。

High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea.

作者信息

Park Su Cheol, Jeong Sook-Hyang, Kim Jin, Han Chul Ju, Kim You Cheoul, Choi Kui Sung, Cho Jang Hyun, Lee Myoungjin, Jung Ha Hyun, Ki Seung Seog, Chang Yoon Hwan, Lee Seung Sook, Park Yeon Hee, Lee Kee Ho

机构信息

Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, South Korea.

出版信息

J Med Virol. 2008 Jun;80(6):960-6. doi: 10.1002/jmv.21168.

DOI:10.1002/jmv.21168

PMID:18428141

Abstract

This study assessed the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with non-Hodgkin's lymphoma in a highly HBV-endemic area. The prevalence of either HBV or HCV infection in 235 patients with non-Hodgkin's lymphoma was compared with that of an age- and sex-matched hospital control group of 235 patients. The prevalence of HBV infection was higher in B-cell non-Hodgkin's lymphoma (15.5%) than control (8.1%), but the prevalence of HCV infection in the non-Hodgkin's lymphoma patients (2.1%) and control group (3%) was similar. HBV prevalence increased significantly with age in the B-cell non-Hodgkin's lymphoma patients. The presence of HBV proteins and DNA in lymphoma tissues and peripheral blood mononuclear cells (PBMCs) from HBV-infected non-Hodgkin's lymphoma patients was also investigated using immunohistochemistry and PCR. HBV DNA was frequently detected in PBMCs from HBV-infected non-Hodgkin's lymphoma patients, but HBV antigens were not. Therefore, HBV infection, but not HCV infection, was associated with B-cell non-Hodgkin's lymphoma in Korea, suggesting a possible role for HBV in the development of non-Hodgkin's lymphoma.

摘要

本研究评估了在乙肝病毒（HBV）高度流行地区，乙肝病毒（HBV）和丙肝病毒（HCV）感染与非霍奇金淋巴瘤之间的关联。将235例非霍奇金淋巴瘤患者的HBV或HCV感染患病率与235例年龄和性别匹配的医院对照组患者进行比较。B细胞非霍奇金淋巴瘤患者的HBV感染患病率（15.5%）高于对照组（8.1%），但非霍奇金淋巴瘤患者（2.1%）和对照组（3%）的HCV感染患病率相似。在B细胞非霍奇金淋巴瘤患者中，HBV患病率随年龄显著增加。还使用免疫组织化学和聚合酶链反应（PCR）研究了HBV感染的非霍奇金淋巴瘤患者的淋巴瘤组织和外周血单个核细胞（PBMC）中HBV蛋白和DNA的存在情况。在HBV感染的非霍奇金淋巴瘤患者的PBMC中经常检测到HBV DNA，但未检测到HBV抗原。因此，在韩国，HBV感染而非HCV感染与B细胞非霍奇金淋巴瘤相关，提示HBV在非霍奇金淋巴瘤发生中可能起作用。