Field H P, Whitley A J, Srinivasan T R, Walker B E, Kelleher J
Department of Medicine, St. James's University Hospital, Leeds.
Int J Vitam Nutr Res. 1987;57(3):311-7.
Plasma, mononuclear cell and granulocyte zinc were assessed in a group of 15 institutionalised elderly female patients, and the effect of different levels of zinc supplements (50, 100, 150 mg elemental zinc/day) on these parameters was measured. Plasma but not cellular zinc was lower in the elderly compared with a young control group, but a diminished serum albumin may explain the plasma results. Plasma zinc increased with supplementation, but only when the daily intake was 100 or 150 mg/day; the greatest response was with the higher dose. Mononuclear cell zinc did not respond to zinc supplements. There was a decrease in granulocyte zinc at all levels of zinc supplements, the greatest decrease being found with the highest dose (150 mg/day). The decrease in granulocyte zinc at high intakes may have implications in phagocytosis and chemotaxis.
对15名住养老院的老年女性患者进行了血浆、单核细胞和粒细胞锌含量的评估，并测定了不同水平锌补充剂（50、100、150毫克元素锌/天）对这些参数的影响。与年轻对照组相比，老年人血浆锌含量较低，但细胞锌含量无差异，不过血清白蛋白降低可能解释了血浆锌结果。补充锌后血浆锌含量增加，但仅在每日摄入量为100或150毫克/天时；剂量越高反应越大。单核细胞锌含量对锌补充剂无反应。所有锌补充剂水平下粒细胞锌含量均降低，最高剂量（150毫克/天）时降低幅度最大。高摄入量时粒细胞锌含量降低可能对吞噬作用和趋化性有影响。
