Sun Xiaoliang, Liu Jun, Ji Haoyang, Yang Meng, Lu Yao
Department of General Surgery, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Cancer Manag Res. 2021 Feb 17;13:1601-1607. doi: 10.2147/CMAR.S299066. eCollection 2021.
Breast cancer (BC) in young women tends to be more aggressive. This study highlights the clinicopathological features and outcomes of young breast cancer (YBC) patients in a developing country.
Consecutive patients aged 35 years or younger with a pathologically confirmed diagnosis of breast cancer treated and followed up at our department were included. Medical records and follow-up databases were reviewed and documented.
The rate of breast conservation and reconstruction surgery is higher in YBC patients. YBC patients are more likely to have tumors over 5cm, high-grade, hormone receptor negative, triple negative and stage III than old patients. There was no statistically significant difference in the pathological type, lymph node metastasis, and HER2 status. The median follow-up time was 96 months. The disease-free survival (DFS) was significantly worse in the YBC group. However, the overall survival (OS) had no difference between the two groups.
YBC patients had more aggressive pathological features, such as hormone receptor negative, triple negative, high-grade and advanced stage, and poorer DFS than the old counterparts.
年轻女性乳腺癌往往更具侵袭性。本研究着重探讨发展中国家年轻乳腺癌（YBC）患者的临床病理特征及预后情况。
纳入在我院接受治疗及随访、年龄35岁及以下且经病理确诊为乳腺癌的连续病例。查阅并记录病历及随访数据库。
YBC患者保乳及重建手术率更高。与老年患者相比，YBC患者更易出现肿瘤直径超过5cm、高级别、激素受体阴性、三阴性及III期情况。病理类型、淋巴结转移及HER2状态方面无统计学显著差异。中位随访时间为96个月。YBC组无病生存期（DFS）显著更差。然而，两组总生存期（OS）无差异。
YBC患者具有更具侵袭性的病理特征，如激素受体阴性、三阴性、高级别及晚期，且与老年患者相比DFS更差。
