Arikan Akif Enes, Kara Halil, Dülgeroğlu Onur, Erdoğan Esin Nur, Capkinoglu Emir, Uras Cihan
Department of General Surgery, Acibadem Mehmet Ali Aydinlar University, School of Medicine, Istanbul, Turkey.
Research Institute of Senology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Front Surg. 2022 Oct 19;9:900363. doi: 10.3389/fsurg.2022.900363. eCollection 2022.
Breast cancer is the most frequently detected cancer and the leading cause of cancer-related death in women. Although it is mostly seen in older patients, breast cancer affects women aged 24 to >70 years, with poorer prognosis in young patients. Young age remains a controversial topic in the literature. This study aimed to identify subtype differences and the effect of age on early-stage breast cancer outcomes.
A total of 300 consecutive patients underwent surgery between 2011 and 2015 for early-stage breast cancer. Of these, 248 were eligible for this study and were divided into three groups: group Y (aged ≤35 years), group M (aged >35 and ≤45 years), and group E (aged >45 years). The clinical and pathological features and data related to recurrence, metastasis, and death were recorded.
No statistical differences were found between groups regarding histopathological features except for higher histological grade and Ki-67 levels in group M. Additionally, group Y recorded no progression (recurrence or metastasis) or death. Disease-free survival was 117.8 months (95% CI 111.8-123.8) for group M, which was significantly shorter than that for group E ( < 0.001). Additionally, the hazard ratio (HR) for progression from group M to group E was 10.21 with significant difference ( = 0.003, 95% CI 2.26-46.08). However, the HR of group Y to group E was 0.04, without significance ( = 0.788, 95% CI 0.18-345 × 10). The overall 5-year survival was 100% in group Y, 98.8% in group M, and 99.3% in group E, without significance.
A very young age cannot be considered an independent risk factor for poor prognosis. Rather than age, histological grade and Ki-67 index are more important factors in early-stage breast cancer.
乳腺癌是女性中最常被检测出的癌症，也是癌症相关死亡的主要原因。尽管乳腺癌多见于老年患者，但它也会影响24岁至70岁以上的女性，年轻患者的预后较差。年轻在文献中仍是一个有争议的话题。本研究旨在确定亚型差异以及年龄对早期乳腺癌预后的影响。
2011年至2015年间，共有300例连续接受早期乳腺癌手术的患者。其中，248例符合本研究条件，并被分为三组：Y组（年龄≤35岁）、M组（年龄>35岁且≤45岁）和E组（年龄>45岁）。记录临床和病理特征以及与复发、转移和死亡相关的数据。
除M组组织学分级和Ki-67水平较高外，各组间组织病理学特征无统计学差异。此外，Y组未记录到进展（复发或转移）或死亡。M组的无病生存期为117.8个月（95%CI 111.8 - 123.8），显著短于E组（<0.001）。此外，M组进展至E组的风险比（HR）为10.21，差异有统计学意义（=0.003，95%CI 2.26 - 46.08）。然而，Y组至E组的HR为0.04，无统计学意义（=0.788，95%CI 0.18 - 345×10）。Y组、M组和E组的总体5年生存率分别为100%、98.8%和99.3%，无统计学意义。
非常年轻的年龄不能被视为预后不良的独立危险因素。在早期乳腺癌中，组织学分级和Ki-67指数比年龄更重要。
