系统免疫炎症指数是肝移植治疗肝内胆管细胞癌患者的预后预测指标。
Systemic Immune-Inflammation Index Is a Prognostic Predictor in Patients with Intrahepatic Cholangiocarcinoma Undergoing Liver Transplantation.
机构信息
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Mediators Inflamm. 2021 Feb 15;2021:6656996. doi: 10.1155/2021/6656996. eCollection 2021.
BACKGROUND
It was reported that systemic immune inflammation index (SII) was related to poor prognosis in a variety of cancers. We aimed to investigate the ability of the prognostic predictors of SII in patients with intrahepatic cholangiocarcinoma (iCCA) undergoing liver transplantation (LT).
METHODS
The 28 iCCA patients who underwent LT at our hospital between 2013 and 2018 were reviewed. Kaplan-Meier survival curves and Cox regression analyses were used to evaluate the prognostic significance of SII. Patients were divided into the high and low SII groups according to the cut-off value.
RESULTS
The 1-, 3-, and 5-year OS rates were significantly lower in the high SII group (85.7%, 28.6%, and 21.4%, respectively) than in the low SII group (92.9%, 71.4%, and 57.2%, respectively; = 0.009). The 1-, 3-, and 5-year RFS rates were, respectively, 57.1%, 32.7%, and 21.8% in the high SII group and 85.7%, 61.1%, and 61.1% in the low SII group ( = 0.021). SII ≥ 447.48 × 10/L (HR 0.273, 95% CI 0.082-0.908; = 0.034) was an independent prognostic factor for OS.
CONCLUSIONS
Our results showed that SII can be used to predict the survival of patients with iCCA who undergo LT.
背景
有报道称，全身免疫炎症指数（SII）与多种癌症的预后不良有关。我们旨在探讨 SII 对接受肝移植（LT）的肝内胆管癌（iCCA）患者预后预测的能力。
方法
回顾了 2013 年至 2018 年在我院接受 LT 的 28 例 iCCA 患者。采用 Kaplan-Meier 生存曲线和 Cox 回归分析评估 SII 的预后意义。根据截断值将患者分为高 SII 组和低 SII 组。
结果
高 SII 组（85.7%、28.6%和 21.4%）的 1、3 和 5 年 OS 率明显低于低 SII 组（92.9%、71.4%和 57.2%；=0.009）。高 SII 组的 1、3 和 5 年 RFS 率分别为 57.1%、32.7%和 21.8%，低 SII 组分别为 85.7%、61.1%和 61.1%（=0.021）。SII≥447.48×10/L（HR 0.273，95%CI 0.082-0.908；=0.034）是 OS 的独立预后因素。
结论
我们的研究结果表明，SII 可用于预测接受 LT 的 iCCA 患者的生存情况。
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