Wasana Keddagoda Gamage Piyumi, Attanayake Anoja Priyadarshani, Jayatilaka Kamani Ayoma Perera Wijewardana, Weerarathna Thilak Priyantha
Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Department of Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Evid Based Complement Alternat Med. 2021 Feb 9;2021:6644004. doi: 10.1155/2021/6644004. eCollection 2021.
The use of medicinal plant extracts and their isolated bioactive compounds for the management of diabetes mellitus has been tremendously increased in recent decades. The present study aimed at providing in-depth information on medicinal flora that has been widely used in the Sri Lankan traditional healthcare system for the management of diabetes mellitus. The data of this review article were obtained from published articles from January 2000 to September 2020 in scientific databases of PubMed, Web of Science, and Google Scholar. In this review, a total number of 18 medicinal plants with the antidiabetic activity were expressed, and their isolated antidiabetic active compounds were highlighted as new drug leads. Results of the reported studies revealed that medicinal plants exert a potent antidiabetic activity via both in vitro and in vivo study settings. However, bioactive compounds and antidiabetic mechanism (s) of action of many of the reported medicinal plants have not been isolated/elucidated the structure in detail, to date. Reported antidiabetic medicinal plants with other properties such as antioxidant and antihyperlipidemic activities deliver new entities for the development of antidiabetic agents with multiple therapeutic targets. This is a comprehensive review on potential antidiabetic activities of the Sri Lankan medicinal plants that have been widely used in the traditional healthcare system. The information presented here would fill the gap between the use of them by traditional healers in the traditional medicine healthcare system in Sri Lanka and their potency for development of new drug entities in future.
近几十年来，药用植物提取物及其分离出的生物活性化合物在糖尿病管理中的应用大幅增加。本研究旨在深入介绍斯里兰卡传统医疗体系中广泛用于糖尿病管理的药用植物。这篇综述文章的数据来自2000年1月至2020年9月发表在PubMed、科学网和谷歌学术等科学数据库中的文章。在本综述中，共列出了18种具有抗糖尿病活性的药用植物，并强调了其分离出的抗糖尿病活性化合物可作为新药先导。报道的研究结果表明，药用植物在体外和体内研究环境中均具有强大的抗糖尿病活性。然而，迄今为止，许多报道的药用植物的生物活性化合物及其抗糖尿病作用机制尚未得到详细分离/阐明其结构。报道的具有抗氧化和抗高血脂等其他特性的抗糖尿病药用植物为开发具有多种治疗靶点的抗糖尿病药物提供了新的实体。这是一篇关于斯里兰卡传统医疗体系中广泛使用的药用植物潜在抗糖尿病活性的综合综述。这里提供的信息将填补斯里兰卡传统医学医疗体系中传统治疗师对它们的使用与未来开发新药物实体的潜力之间的空白。
