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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)RNA在一名患有代谢综合征的男性体内持续存在72天:病例报告

Persistence of SARS-CoV-2 RNA in a male with metabolic syndrome for 72 days: A case report.

作者信息

Islam Sm Rashed Ul, Akther Tahmina, Sultana Sharmin, Munshi Saif Ullah

机构信息

Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

出版信息

SAGE Open Med Case Rep. 2021 Jan 23;9:2050313X21989492. doi: 10.1177/2050313X21989492. eCollection 2021.

Abstract

Coronavirus disease-19 (COVID-19) was first identified in Wuhan, China, and spread gradually throughout the world. There are multiple reports of prolonged viral shedding in people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, such findings have not been documented in Bangladesh. Herein, we present a case of metabolic syndrome that remained positive for SARS-CoV-2 RNA over a prolonged period. On clinical and laboratory examination, the patient was diagnosed with obesity, raised blood pressure, dyslipidemia, and uncontrolled glycemia. However, upon taking appropriate measures and controlling the plasma sugar level, he tested negative for SARS-CoV-2 RNA on the 72nd day since illness onset. We observed that COVID-19 patients with several comorbidities, such as metabolic syndrome, may shed the virus over a prolonged period. Therefore, strict public health measures and isolation rules should be followed by a high-risk population.

摘要

新型冠状病毒肺炎(COVID-19)最初在中国武汉被发现,并逐渐蔓延至全球。有多项报告指出,感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的患者存在病毒长期脱落的情况;然而,孟加拉国尚未有此类发现的记录。在此,我们报告一例代谢综合征患者,其SARS-CoV-2 RNA在较长时间内呈阳性。经临床和实验室检查,该患者被诊断为肥胖、血压升高、血脂异常和血糖控制不佳。然而,在采取适当措施并控制血糖水平后,自发病第72天起,他的SARS-CoV-2 RNA检测呈阴性。我们观察到,患有多种合并症(如代谢综合征)的COVID-19患者可能会长期排出病毒。因此,高危人群应严格遵守公共卫生措施和隔离规定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5051/7841660/a386e4d3fd3c/10.1177_2050313X21989492-fig1.jpg

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