Karataş Ayşe, İnkaya Ahmet Çağkan, Demiroğlu Haluk, Aksu Salih, Haziyev Tahmaz, Çınar Olgu Erkin, Alp Alpaslan, Uzun Ömrüm, Sayınalp Nilgün, Göker Hakan
Hacettepe University Faculty of Medicine, Department of Internal Medicine, Hematology Unit, Ankara, Turkey.
Hacettepe University Faculty of Medicine, Department of Infectious Diseases, Ankara, Turkey.
Transfus Apher Sci. 2020 Oct;59(5):102871. doi: 10.1016/j.transci.2020.102871. Epub 2020 Jul 3.
Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative in 20 days post-infection, but prolonged positivity has been reported up to 63 days. A case whose viral shedding lasted 60 days is reported from China. Herein we report a patient with a history of autologous stem cell transplantation (ASCT) for lymphoma whose RT-PCR test remained positive for SARS-CoV-2 for 74 days. The prolonged RT-PCR positivity, despite convalescent plasma infusion, may suggest that the given antibodies may be ineffective in terms of viral clearance. In patients with hematological malignancies or immunosuppression, such as ASCT, may lead to prolonged viral shedding, and strict isolation is warranted for long-term SARS-CoV-2 infection control.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）最初在中国武汉被发现，并传播至全球。SARS-CoV-2的逆转录聚合酶链反应（RT-PCR）检测通常在感染后20天转为阴性，但也有报道称阳性结果会持续长达63天。中国报告了1例病毒脱落持续60天的病例。在此，我们报告1例因淋巴瘤接受自体干细胞移植（ASCT）的患者，其SARS-CoV-2的RT-PCR检测在74天内一直呈阳性。尽管输注了康复期血浆，但RT-PCR阳性结果持续时间延长，这可能表明所给予的抗体在病毒清除方面可能无效。对于血液系统恶性肿瘤或免疫抑制患者，如接受ASCT的患者，可能会导致病毒脱落时间延长，因此有必要进行严格隔离以长期控制SARS-CoV-2感染。
