Desai Shivani, Bhonde Ramesh R, Parekh Sameer S
Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, India.
Dr. D. Y. Patil Vidyapeeth, Pune, India.
Clin Exp Vaccine Res. 2021 Jan;10(1):1-5. doi: 10.7774/cevr.2021.10.1.1. Epub 2021 Jan 31.
The incidence of type 1 diabetes mellitus (T1DM), an autoimmune disorder, has ascended considerably with around 98,200 and 15,900 incidents in children below 15 years of age, globally and in India, respectively. This is typically due to environmental changes leading to genetic modifications. Also, T1DM encompasses the presence of autoantigens and many other etiologies which can be targeted by proper immunization. In this paper, we consciously discuss and collate various candidate triggers of islet autoimmunity and other factors expected to promote progression of T1DM. This paper bridges all the mechanisms caused by these factors and linking them with each other. We have also highlighted on the novel corona virus as a trigger for T1DM. Finally, we suggest that an amalgamated model of polyvaccine can batter the condition by inducing protection against various triggers of T1DM.
1型糖尿病（T1DM）是一种自身免疫性疾病，在全球和印度，15岁以下儿童的发病率分别大幅上升至约98,200例和15,900例。这通常是由于环境变化导致基因改变。此外，T1DM包括自身抗原的存在以及许多其他病因，这些病因可通过适当的免疫接种来靶向治疗。在本文中，我们有意识地讨论并整理了胰岛自身免疫的各种候选触发因素以及其他预计会促进T1DM进展的因素。本文阐述了由这些因素引起的所有机制，并将它们相互联系起来。我们还强调了新型冠状病毒作为T1DM的触发因素。最后，我们建议多疫苗联合模型可以通过诱导针对T1DM各种触发因素的保护作用来改善病情。
