Park C H
University of Kansas Medical Center, Kansas City 66103.
Prog Clin Biol Res. 1988;259:321-30.
Vitamin C was shown to be an essential requirement for the growth of mouse myeloma cells in an in vitro colony assay. Human leukemia (acute nonlymphocytic leukemia) cell colonies grow well in a similar in vitro culture system, and vitamin C has been shown to enhance the growth of leukemic cell colonies in 77 (35%) of 219 leukemic patients while none of 34 normal bone marrows tested simultaneously shows growth enhancement by this vitamin. This vitamin C effect is reproducible in repeated experiments in same patients, specific to this vitamin, selective for leukemic cells, and is proven to be biological in nature. Further, leukemic cells are mobilized back and forth between cycling and resting states with vitamin C supplementation/depletion. Our more recent study indicates that the preleukemia (myelodysplastic syndrome), generally known to be related to acute nonlymphocytic leukemia, has similar pattern in terms of vitamin C sensitivity, with 8 of 25 patients (32%) showing the growth enhancement with this vitamin.
在体外集落测定中，维生素C被证明是小鼠骨髓瘤细胞生长的必需物质。人类白血病（急性非淋巴细胞白血病）细胞集落在类似的体外培养系统中生长良好，并且在219例白血病患者中，有77例（35%）的白血病细胞集落生长因维生素C而增强，而同时检测的34例正常骨髓中无一例显示该维生素能促进生长。这种维生素C效应在对同一患者的重复实验中是可重现的，对该维生素具有特异性，对白血病细胞具有选择性，并且已被证明本质上是生物学效应。此外，补充/去除维生素C会使白血病细胞在循环和静止状态之间来回转换。我们最近的研究表明，通常认为与急性非淋巴细胞白血病相关的白血病前期（骨髓增生异常综合征）在维生素C敏感性方面具有相似模式，25例患者中有8例（32%）显示该维生素能促进生长。
