Division of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.
Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.
Biomed Res Int. 2021 Feb 8;2021:7656843. doi: 10.1155/2021/7656843. eCollection 2021.
We enrolled pediatric subjects with developmental dyslexia and, as a control group, healthy age- and sex-matched subjects without developmental dyslexia. Thyroid function was evaluated in subjects with developmental dyslexia measuring serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). Thyroid autoimmunity was evaluated in all subjects measuring antithyroid peroxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibodies. In subjects with developmental dyslexia, thyroid ultrasonography (US) was also performed.
We enrolled 51 subjects with developmental dyslexia (M : F = 39 : 12, mean age 12.4 ± 9 years) and 34 controls (M : F = 24 : 10, mean age 10.8 ± 4 years). TPO-Ab positivity was significantly higher in subjects with developmental dyslexia compared to controls (60.8% vs. 2.9%, < 0.001), while no significant difference was found in TG-Ab positivity (16% vs. 5.8%). Thyroid US performed in 49 subjects with developmental dyslexia revealed a thyroiditis pattern in 60%.
We found an extremely high prevalence of thyroid autoimmunity in children with developmental dyslexia. Further studies are needed to confirm our observations, but our findings may change the approach to this disorder and eventually lead to a systematic determination of thyroid autoimmunity in children with developmental dyslexia.
我们招募了患有发育性阅读障碍的儿科患者，并招募了健康的、年龄和性别匹配的、无发育性阅读障碍的对照组患者。通过测量促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）的血清浓度，评估发育性阅读障碍患者的甲状腺功能。通过测量抗甲状腺过氧化物酶（TPO-Ab）和抗甲状腺球蛋白（TG-Ab）抗体，评估所有患者的甲状腺自身免疫情况。对患有发育性阅读障碍的患者还进行了甲状腺超声（US）检查。
我们共招募了 51 名患有发育性阅读障碍的患者（男：女=39：12，平均年龄 12.4±9 岁）和 34 名对照组患者（男：女=24：10，平均年龄 10.8±4 岁）。与对照组相比，患有发育性阅读障碍的患者 TPO-Ab 阳性率明显更高（60.8% vs. 2.9%， < 0.001），而 TG-Ab 阳性率无明显差异（16% vs. 5.8%）。对 49 名患有发育性阅读障碍的患者进行的甲状腺超声检查显示，60%的患者存在甲状腺炎模式。
我们发现患有发育性阅读障碍的儿童中甲状腺自身免疫的发生率极高。需要进一步的研究来证实我们的观察结果，但我们的发现可能会改变对这种疾病的治疗方法，并最终导致对患有发育性阅读障碍的儿童进行甲状腺自身免疫的系统检测。
