Ghosh Prasanjit, Ganguly Bhaskar, Das Sajal
Department of Chemistry, University of North Bengal, Darjeeling - 734013, India.
Org Biomol Chem. 2021 Mar 18;19(10):2146-2167. doi: 10.1039/d0ob02169e.
In modern organic synthesis, the execution of reactions in the absence of expensive transition metals has received significant attention from the view-point of green chemistry and sustainable development. As a consequence, the combination of MI-TBHP as an oxidation system (M = Na, K, NH4) has opened a new avenue with significant impact for the succinct synthesis of complex heterocycle molecules via the construction of various chemical bonds [C-X (X = C, N, S, O), N-X (X = N, P) and S-N]. This comprehensive review article delineates the progress of recent developments in this emerging area, with an in-depth discussion on the substrate scope, limitations and proper mechanistic underpinnings. We hope this review will highlight the great potential of this MI-TBHP as a powerful oxidation system and inspire researchers to conduct further endeavors in this domain.
在现代有机合成中，从绿色化学和可持续发展的角度来看，在无昂贵过渡金属条件下进行反应受到了广泛关注。因此，以MI-TBHP（M = Na、K、NH4）作为氧化体系，通过构建各种化学键[C-X（X = C、N、S、O）、N-X（X = N、P）和S-N]来简洁合成复杂杂环分子，开辟了一条具有重大影响的新途径。这篇综述文章阐述了这一新兴领域的最新进展，并对底物范围、局限性及适当的反应机理进行了深入讨论。我们希望这篇综述能突出MI-TBHP作为一种强大氧化体系的巨大潜力，并激励研究人员在该领域进一步探索。
