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评论 - CRISPR 技术:Cas9、Cas13 及其在 COVID-19 时代的应用。

Commentary - CRISPR-based techniques: Cas9, Cas13 and their applications in the era of COVID-19.

机构信息

Department of Anatomical Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Italy.

出版信息

Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1752-1761. doi: 10.26355/eurrev_202102_24886.

Abstract

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein 9) system enables scientists to edit diverse genome types with relative ease, with the aim - in the near future - to prevent future human beings from developing genetic diseases. The new opportunities arising from the system are broad-ranging and revolutionary, but such prospects have also been the cause for alarm throughout the international scientific community. The authors have laid out a review of the trials carried out so far in terms of genome editing, for the ultimate purpose of weighing implications and criticisms. We feel that possible valuable alternatives, such as induced pluripotent stem cells should not be overlooked.

摘要

CRISPR(成簇规律间隔短回文重复)/Cas9(CRISPR 相关蛋白 9)系统使科学家能够相对轻松地编辑各种基因组类型,其目的是在不久的将来防止人类患上遗传疾病。该系统带来的新机遇是广泛而具有革命性的,但这些前景也引起了国际科学界的警惕。作者对迄今为止进行的基因组编辑试验进行了回顾,目的是权衡其影响和批评。我们认为,不应忽视可能有价值的替代方案,如诱导多能干细胞。

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