Kafetzopoulos E
Department of Pharmacology, Medical School, University of Ioannina, Greece.
Pharmacol Biochem Behav. 1988 Mar;29(3):457-60. doi: 10.1016/0091-3057(88)90003-2.
Local injection of muscimol into the dorsal or ventral striatum of rats did not induce any rotational activity, but injection of picrotoxin into ventral striatal aspects induced an intense contralateral rotation. Amphetamine pretreatment resulted in an ipsilateral rotation after muscimol injection into dorsal striatum and in a complex rotational pattern after ventral injection, characterized by an initial short-lasting ipsilateral rotation followed by a long-lasting contralateral rotation. The contralateral rotation induced by picrotoxin was abolished by amphetamine pretreatment. These results indicate a functional heterogeneity between dorsal and ventral striatal mechanisms mediating rotational behavior, and a different pattern of dopamine-GABA interactions between dorsal and ventral striatum.
向大鼠背侧或腹侧纹状体局部注射蝇蕈醇未诱导出任何旋转活动，但向腹侧纹状体区域注射印防己毒素会诱导强烈的对侧旋转。苯丙胺预处理导致在向背侧纹状体注射蝇蕈醇后出现同侧旋转，而在向腹侧注射后出现复杂的旋转模式，其特征是最初短暂的同侧旋转后接着是持久的对侧旋转。苯丙胺预处理消除了印防己毒素诱导的对侧旋转。这些结果表明，介导旋转行为的背侧和腹侧纹状体机制之间存在功能异质性，并且背侧和腹侧纹状体之间多巴胺 - 伽马氨基丁酸相互作用模式不同。
