Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Department of Dermatology, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Dermatol Ther. 2021 May;34(3):e14915. doi: 10.1111/dth.14915. Epub 2021 Mar 18.
Acne vulgaris is one of the most common dermatologic disorders affects people of all races and ethnicities and has many adverse effects on the quality of life. The increased bacterial resistance to antibiotics has reduced the effectiveness of treatment with these agents. There is an increasing focus on the involvement of oxidative stress in the pathophysiology of acne. This study investigates the effect of N-acetylcysteine (NAC) as an antioxidant in the treatment of acne vulgaris. This systematic review was conducted through a search in databases such as Science Direct, PubMed, Scielo, and Medline using keywords including acne vulgaris, anti and NAC, and all the keywords associated with each of the subtitles. The factors affecting the occurrence and expansion of acne include increased sebum synthesis, hyperkeratinization of pilosebaceous units, colonization with Propionibacterium acnes, and increased release of inflammatory mediators and ROS. Studies have shown that glutathione stimulation following the administration of NAC increases glutathione levels for the detoxification of oxygen-free radicals. Moreover, NAC prevents the synthesis and release of inflammatory cytokines such as TNF-α, IL-8, IL-6, MP9, and IL-1β and has shown antibacterial activities against important bacteria including E. coli, S. epidermidis, Pseudomonas, and Klebsiella. This medication has anti-proliferative effects and is also used for excoriation and PCOD. The results of the present study showed the beneficial effects of using NAC in patients with acne vulgaris in terms of the disease complications and comorbidities. Given its diverse functional mechanisms, this medication can be used to treat acne and its consequences.
寻常痤疮是一种最常见的皮肤科疾病，影响所有种族和民族的人群，对生活质量有许多不良影响。抗生素的细菌耐药性增加降低了这些药物的治疗效果。人们越来越关注氧化应激在痤疮发病机制中的作用。本研究调查了 N-乙酰半胱氨酸（NAC）作为一种抗氧化剂在治疗寻常痤疮中的作用。本系统评价通过在 Science Direct、PubMed、Scielo 和 Medline 等数据库中搜索，使用包括寻常痤疮、抗和 NAC 以及与每个副标题相关的所有关键词进行搜索。影响痤疮发生和发展的因素包括皮脂合成增加、毛囊皮脂腺单位过度角化、痤疮丙酸杆菌定植以及炎症介质和 ROS 的释放增加。研究表明，NAC 给药后谷胱甘肽的刺激增加了谷胱甘肽水平，用于解毒氧自由基。此外，NAC 可预防 TNF-α、IL-8、IL-6、MP9 和 IL-1β 等炎症细胞因子的合成和释放，并对包括大肠杆菌、表皮葡萄球菌、假单胞菌和克雷伯氏菌在内的重要细菌具有抗菌活性。这种药物具有抗增殖作用，也用于搔抓和 PCOD。本研究的结果表明，NAC 对寻常痤疮患者的疾病并发症和合并症有有益的影响。鉴于其多种功能机制，这种药物可用于治疗痤疮及其后果。
