Kosobud A, Bodor A S, Crabbe J C
Department of Medical Psychology, Oregon Health Sciences University, Portland 97201.
Pharmacol Biochem Behav. 1988 Mar;29(3):601-7. doi: 10.1016/0091-3057(88)90026-3.
The genetic correlation between voluntary consumption of ethanol solutions and severity of withdrawal seizures after chronic ethanol exposure was assessed using the selectively bred Withdrawal Seizure Prone (WSP) and Resistant (WSR) mouse lines. WSP mice have at least ten-fold more severe withdrawal than WSR mice after equal chronic ethanol exposure, and withdrawal in a nonselected control line (WSC) is intermediate to withdrawal in the WSP and WSR lines. In the first experiment, mice from the WSP, WSC and WSR lines were offered a choice between 2.2, 4.6 and 10.0% ethanol solutions and water in three consecutive eight-day sessions. WSR mice consumed more ethanol than WSP mice, and WSC mice were intermediate. In a second experiment, WSP and WSR mice were offered ethanol solutions in concentrations that were adjusted up or down every two days depending upon the amount of ethanol consumed. WSP and WSR mice displayed very different patterns of drinking, with WSP mice drinking more ethanol in early stages of the experiment, and WSR mice drinking more ethanol later. Results of these experiments suggest that some genes influencing severity of withdrawal from ethanol also influence voluntary ethanol drinking.
利用选择性培育的易发生戒断性癫痫（WSP）和抗性（WSR）小鼠品系，评估了慢性乙醇暴露后乙醇溶液的自愿摄入量与戒断性癫痫严重程度之间的遗传相关性。在同等慢性乙醇暴露后，WSP小鼠的戒断反应比WSR小鼠严重至少十倍，非选择对照品系（WSC）的戒断反应介于WSP和WSR品系之间。在第一个实验中，连续三个八天的实验阶段为WSP、WSC和WSR品系的小鼠提供2.2%、4.6%和10.0%的乙醇溶液以及水供其选择。WSR小鼠比WSP小鼠摄入更多的乙醇，WSC小鼠的摄入量介于两者之间。在第二个实验中，根据乙醇摄入量每两天上调或下调浓度，为WSP和WSR小鼠提供乙醇溶液。WSP和WSR小鼠表现出非常不同的饮酒模式，WSP小鼠在实验早期摄入更多的乙醇，而WSR小鼠在后期摄入更多的乙醇。这些实验结果表明，一些影响乙醇戒断严重程度的基因也会影响乙醇的自愿摄入量。
