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轻度和重度哮喘患者呼吸微生物组的变化。

The changes of respiratory microbiome between mild and severe asthma patients.

机构信息

Department of Respiratory and Critical Care Medicine, Jinhua People's Hospital, Zhejiang, China.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.

出版信息

Microbiol Immunol. 2021 May;65(5):204-213. doi: 10.1111/1348-0421.12881. Epub 2021 Apr 16.

Abstract

Due to the increased number of patients suffering from asthma, the mechanism of this disease has been subject to much attention from the public and finding a cure for this disease is urgent. A changed abundance of the microbiome has been proven to play an important role in the genesis and development of asthma. In this study, the abundance and the function of the microbiome were studied. It was found that there were significant changes in the components and the function of the microbiome when asthma changed from mild to severe. This study could help us to better understand the relationship between asthma and the respiratory microbiome.

摘要

由于哮喘患者数量的增加,这种疾病的发病机制引起了公众的广泛关注,寻找治疗这种疾病的方法迫在眉睫。大量研究表明,微生物组的改变在哮喘的发生和发展中起着重要作用。在这项研究中,我们研究了微生物组的丰度和功能。结果发现,当哮喘从轻度向重度转变时,微生物组的组成和功能发生了显著变化。这项研究可以帮助我们更好地理解哮喘与呼吸道微生物组之间的关系。

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