Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Dermatitis. 2021;32(6):413-420. doi: 10.1097/DER.0000000000000708.
Contact dermatitis to homemade slime has been frequently reported, with isothiazolinones as a likely sensitizer. Little is known on the presence of these preservatives in commercial, store-bought slime products.
The aims of the study were to review the literature on "slime dermatitis" and to assess for the presence of isothiazolinones in commercially available slime products and homemade slime components.
An experimental, colorimetric spot test was used to verify the presence of isothiazolinones in 38 slime products of the 16 best-selling commercial slime kits, 1 finished homemade slime, and 4 common components of homemade slime. High-performance liquid chromatography with UV detection was performed on 8 commercial slime products.
According to the spot test, 27 (71%) of the 38 commercial slime products contained isothiazolinones. High-performance liquid chromatography with UV detection analyses indicated, however, that false-positives and false-negatives readily occur: isothiazolinone content was correctly identified in only 4 (50%) of the 8 samples.
This study is the first to demonstrate the presence of isothiazolinones in commercial slime toys. Although the colorimetric spot test may have some utility as a screening assay, it is far from specific and likely not sensitive enough to reliably identify methylisothiazolinone.
自制史莱姆引起的接触性皮炎时有报道，异噻唑啉酮类化合物可能是致敏原。市售史莱姆产品中是否含有这些防腐剂，人们知之甚少。
本研究旨在回顾“史莱姆皮炎”的文献，并评估市售史莱姆产品和自制史莱姆成分中是否存在异噻唑啉酮类化合物。
采用实验性比色点测试法，对 16 种最畅销的商业史莱姆套装中的 38 种史莱姆产品、1 种已完成的自制史莱姆以及 4 种自制史莱姆常见成分中异噻唑啉酮类化合物的存在情况进行了验证。对 8 种商业史莱姆产品进行了高效液相色谱-紫外检测分析。
根据点测试，38 种商业史莱姆产品中有 27 种（71%）含有异噻唑啉酮类化合物。然而，高效液相色谱-紫外检测分析表明，很容易出现假阳性和假阴性：8 个样本中只有 4 个（50%）正确识别出异噻唑啉酮类化合物的含量。
本研究首次证明商业史莱姆玩具中存在异噻唑啉酮类化合物。虽然比色点测试法可能具有一定的筛选分析作用，但它远非特异性，而且可能不够敏感，无法可靠地识别甲基异噻唑啉酮。
