Liu Mengxue, Zhang Jiulong, Li Xin, Cai Chao, Cao Xueyan, Shi Xiangyang, Guo Rui
State Key Laboratory of Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, People's Republic of China.
J Mater Chem B. 2019 Jun 19;7(24):3856-3864. doi: 10.1039/c9tb00398c.
The development of theranostic nanoplatforms with accurate diagnosis and effective therapy performance is crucial for precision medicine applications. Herein, we developed a novel targeted theranostic nanoplatform for magnetic resonance (MR) and photoacoustic (PA) imaging-guided photothermal therapy of cancer cells overexpressing sialic acid (SA). Firstly, LAPONITE® (LAP)-stabilized Fe3O4 nanoparticles (NPs) with a high r2 relaxivity were synthesized by a coprecipitation method, and then polydopamine (PDA) was coated to improve the photothermal effect and PA contrast effect, followed by the modification of PEGylated phenylboronic acid (PEG-PBA) to introduce tumor-targeting specificity into SA-overexpressed cancer cells. The formed LAP-Fe3O4@PDA-PEG-PBA NPs show excellent biocompatibility and photothermal conversion efficiency under near-infrared laser irradiation and are able to be used for dual modal MR/PA imaging of a xenografted tumor model and induce complete eradication of tumors after NIR laser treatment. In summary, LAP-Fe3O4@PDA-PEG-PBA NPs could be theranostic nanoplatforms for sensitive MR/PA imaging and effective photothermal therapy of SA-overexpressed tumors.
开发具有准确诊断和有效治疗性能的诊疗纳米平台对于精准医学应用至关重要。在此，我们开发了一种新型靶向诊疗纳米平台，用于对过表达唾液酸（SA）的癌细胞进行磁共振（MR）和光声（PA）成像引导的光热治疗。首先，通过共沉淀法合成了具有高r2弛豫率的LAPONITE®（LAP）稳定的Fe3O4纳米颗粒（NPs），然后包覆聚多巴胺（PDA）以提高光热效应和PA对比效果，接着修饰聚乙二醇化苯硼酸（PEG-PBA）以将肿瘤靶向特异性引入过表达SA的癌细胞中。形成的LAP-Fe3O4@PDA-PEG-PBA NPs在近红外激光照射下表现出优异的生物相容性和光热转换效率，能够用于异种移植肿瘤模型的双模态MR/PA成像，并在近红外激光治疗后诱导肿瘤完全根除。总之，LAP-Fe3O4@PDA-PEG-PBA NPs可以作为用于SA过表达肿瘤的灵敏MR/PA成像和有效光热治疗的诊疗纳米平台。
