Through actual case illustration, I have tried to present the way biopsy of a vesicobullous lesion would be approached by the dermatopathologist. I did not intend this article to be a comprehensive review and, because of the limitation of space, have ommited the more unusual bullous dermatoses. Comprehensive reviews of the role of immunofluorescence in vesicobullous disorders can be found in the Archives of Dermatology and Progress in Dermatology.
