治疗年龄相关性黄斑变性中地图状萎缩的新兴疗法。
Emerging treatments for geographic atrophy in age-related macular degeneration.
机构信息
Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA.
出版信息
Curr Opin Ophthalmol. 2021 May 1;32(3):294-300. doi: 10.1097/ICU.0000000000000746.
PURPOSE OF REVIEW
This review describes therapeutic research programs for geographic atrophy (GA) due to age-related macular degeneration (AMD). We highlight clinical trial data from phase I, II, and III studies.
RECENT FINDINGS
There are currently no treatments for GA, a form of advanced AMD that causes significant visual morbidity. Currently, therapeutic candidates are being developed to delay further progression of GA or even attempt to reverse some of the damage. The approaches to therapy range from molecular targets to cell transplantation. Studies of these novel treatment approaches have demonstrated varying degrees of success. The progress in understanding the disease pathophysiology as well as clinical trial data is reviewed.
SUMMARY
There are promising new treatments to prevent GA progression as well as some that may reverse the disease course.
目的综述
本文描述了与年龄相关性黄斑变性（AMD）相关的地图状萎缩（GA）的治疗研究计划。我们重点介绍了 I 期、II 期和 III 期研究的临床试验数据。
最近的发现
目前尚无针对 GA 的治疗方法，GA 是一种导致严重视觉发病率的晚期 AMD 形式。目前，正在开发治疗候选药物以延迟 GA 的进一步进展，甚至试图逆转部分损伤。治疗方法从分子靶标到细胞移植不等。这些新型治疗方法的研究取得了不同程度的成功。本文回顾了对疾病病理生理学的理解以及临床试验数据的进展。
总结
有一些很有前途的新疗法可以预防 GA 的进展，还有一些可能逆转疾病进程。
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