College of Population Health, Thomas Jefferson University, Philadelphia, USA.
Indian Health Outcomes, Public Health and Economics (IHOPE) Research Centre, India.
Indian J Ophthalmol. 2023 Oct;71(10):3361-3366. doi: 10.4103/IJO.IJO_199_23.
To report a big data analysis of risk and protective factors in patients with AMD, as well as report on the age-adjusted prevalence in a geriatric Indian cohort in a hospital setting.
This retrospective, observational study of all patients older than 60 years of age. Multiple logistic regression was performed for the binary outcome and the presence of AMD. Variables analyzed include age, gender, socioeconomic status, occupation, urban-rural-metropolitan distribution, self-reported history of diabetes mellitus (DM), hypertension (HTN), or coronary artery disease (CAD), ocular comorbidities, history of cataract surgery, and presenting VA. Odds ratios (OR) and 99% confidence intervals were calculated.
Of the 608,171 patients over the age of 60 years who attended our clinics, 1.68% of subjects had a diagnosis of AMD (N = 10,217). Less than half (4,621 of 10,217 with AMD) of them were diagnosed to have dry AMD. Cataract, glaucoma, and diabetic retinopathy were associated with lower risk of AMD. Cataract surgery was associated with the higher risk of AMD (OR = 1.20; 99% CI 1.13-1.29). Smoking was not associated with AMD.
Big data analysis from a hospital setting shows that the prevalence of AMD above the age of 60 years is low. More patients with wet AMD present for treatment compared to dry AMD. Smoking was not associated with AMD in the Indian population. Cataract surgery was associated with higher prevalence of AMD.
报告一项关于 AMD 患者风险和保护因素的大数据分析，并报告在医院环境中印度老年队列的年龄调整患病率。
这是一项回顾性、观察性研究，纳入所有年龄在 60 岁以上的患者。对二项结果和 AMD 的存在进行多元逻辑回归分析。分析的变量包括年龄、性别、社会经济状况、职业、城乡-都会分布、自我报告的糖尿病史 (DM)、高血压 (HTN) 或冠状动脉疾病 (CAD)、眼部合并症、白内障手术史和当前 VA。计算了比值比 (OR) 和 99%置信区间。
在 608171 名 60 岁以上就诊于我们诊所的患者中，有 1.68%（N=10217）的患者被诊断为 AMD。不到一半（干 AMD，4621/10217）的患者被诊断为干 AMD。白内障、青光眼和糖尿病性视网膜病变与 AMD 的风险降低相关。白内障手术与 AMD 的风险增加相关（OR=1.20；99%CI1.13-1.29）。吸烟与 AMD 无关。
来自医院环境的大数据分析显示，60 岁以上人群 AMD 的患病率较低。与干 AMD 相比，更多的湿性 AMD 患者接受治疗。在印度人群中，吸烟与 AMD 无关。白内障手术与 AMD 的患病率升高相关。
