FDG PET 揭示副肿瘤性小脑变性的病程：半定量分析。

FDG PET Unveils the Course of Paraneoplastic Cerebellar Degeneration: A Semiquantitative Analysis.

机构信息

From the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa.

Department of Health Science, University of Genoa, Genoa, Italy.

出版信息

Clin Nucl Med. 2021 Jun 1;46(6):e327-e328. doi: 10.1097/RLU.0000000000003547.

DOI:10.1097/RLU.0000000000003547

PMID:33630801

Abstract

In paraneoplastic cerebellar degeneration (PCD), the standard diagnostic workup might be inconclusive, especially in seronegative subtypes. Brain 18F-FDG PET is an accurate supportive diagnostic tool in immune-mediated disorders, but findings in PCD are controversial. Semiquantitative analysis of 18F-FDG PET can meaningfully assist visual assessment in different neurological conditions and has been mainly applied to disclose regional hypometabolism. We describe a seronegative PCD associated with small cell lung cancer in which 18F-FDG PET semiquantitative analysis accurately disclosed the longitudinal pathological changes of brain metabolism occurring in the acute and posttreatment remission stages and paralleling clinical impairment and response to treatment.

摘要

在副肿瘤性小脑变性（PCD）中，标准的诊断性检查可能没有定论，尤其是在血清阴性亚型中。18F-FDG PET 脑显像在免疫介导性疾病中是一种准确的辅助诊断工具，但在 PCD 中的应用结果存在争议。18F-FDG PET 的半定量分析在不同的神经疾病中可以有意义地辅助视觉评估，并且主要应用于揭示区域性低代谢。我们描述了一例与小细胞肺癌相关的血清阴性 PCD，18F-FDG PET 半定量分析准确地揭示了在急性和治疗后缓解阶段发生的脑代谢的纵向病理变化，与临床损伤和对治疗的反应平行。