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[γ射线照射的中国仓鼠细胞中DNA单链断裂的诱导修复]

[Inducible repair of DNA single-strand breaks in gamma-irradiated Chinese hamster cells].

作者信息

Seregina T B, Zhestianikov V D

出版信息

Radiobiologiia. 1988 Mar-Apr;28(2):205-9.

PMID:3363097
Abstract

Preirradiation of Chinese hamster cells with low-level UV-light does not influence the efficiency of repair of gamma-radiation-induced DNA single-strand breaks. With fractionated gamma-irradiation, cycloheximide delivered during the interval between the two fractions reduces the number of DNA breaks (compared to that in cells affected by the same nonfractionated dose). The data obtained indicate the presence of an inducible component of repair of DNA single-strand breaks in gamma-irradiated Chinese hamster cells.

摘要

用低水平紫外线对中国仓鼠细胞进行预照射,不会影响γ射线诱导的DNA单链断裂的修复效率。对于分次γ射线照射,在两次照射间隔期间给予环己酰亚胺,会减少DNA断裂的数量(与受相同非分次剂量照射的细胞相比)。所获得的数据表明,在γ射线照射的中国仓鼠细胞中存在DNA单链断裂修复的可诱导成分。

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