Taniguchi Ryo, Noto Naoki, Tanaka Seiya, Takahashi Keigo, Sarkar Sujan K, Oyama Ryoko, Abe Manabu, Koike Takashi, Akita Munetaka
School of Materials and Chemical Technology, Tokyo Institute of Technology, R1-27, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.
Department of Chemistry, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.
Chem Commun (Camb). 2021 Mar 11;57(21):2609-2612. doi: 10.1039/d0cc08060h.
A metal-free and operationally simple strategy for the generation of various α-monofluoroalkyl radicals has been developed. A combination of 1,4-bis(diarylamino)naphthalene photocatalyst and sulfoximine-based fluoroalkylating reagents is the key to success. The protocol can be applied to modular synthesis of β-monofluoroketones through radical monofluoroalkylation of alkenyl acetates.
已开发出一种用于生成各种α-单氟烷基自由基的无金属且操作简单的策略。1,4-双（二芳基氨基）萘光催化剂和基于亚磺酰亚胺的氟烷基化试剂的组合是成功的关键。该方案可通过醋酸烯基酯的自由基单氟烷基化应用于β-单氟酮的模块化合成。
