Hou Zhong-Wei, Jiang Ting, Wu Ting-Xia, Wang Lei
Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou, Zhejiang 318000, P. R. China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China.
Org Lett. 2021 Nov 5;23(21):8585-8589. doi: 10.1021/acs.orglett.1c03284. Epub 2021 Oct 26.
An electrochemical approach for the preparation of monofluorides from α,β-unsaturated carboxylic acids and heteroaromatics with readily available 2-fluoromalonate esters as monofluoroalkyl radical precursors has been developed. The electrosynthesis employs ferrocene (CpFe) as a catalyst in a simple undivided cell with a broad substrate scope, which obviates the need for sacrificial oxidizing reagents.
已开发出一种电化学方法，以易于获得的2-氟丙二酸酯作为单氟烷基自由基前体，从α,β-不饱和羧酸和杂芳烃制备单氟化物。该电合成在一个简单的无隔膜电池中使用二茂铁（CpFe）作为催化剂，底物范围广泛，无需使用牺牲性氧化试剂。
