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[单独照射自体血对长期白细胞减少实验模型中白细胞生成恢复的影响]

[Effect of autologous blood irradiated in isolation on the restoration of leukopoiesis in an experimental model of prolonged leukopenia].

作者信息

Moskalenko I P, Nikiforova N A, Martyniuk N M, Ishkhanova M A, Ronin V S

出版信息

Radiobiologiia. 1988 Mar-Apr;28(2):240-4.

PMID:3363104
Abstract

Reinfusion of irradiated (220 Gy) isolated blood (IIB) was shown to accelerate leukopoiesis restoration in conditions of myelodepression induced by the injection of cyclophosphane. Restoration of leucocyte count in the peripheral blood was preceded by the increase in DNA synthesis and bone marrow cellularity. Reinfusion of IIB also promoted a more rapid restoration of cellularity of lymphoid organs with cAMP predominating therein. The comparison of the processes under study in time permits to assume that the stimulatory effect of IIB is related to activation of proliferation and stimulation of cell maturing in bone marrow and lymphoid organs.

摘要

经照射(220戈瑞)的分离血液(IIB)回输已显示,在注射环磷酰胺诱导的骨髓抑制情况下,可加速白细胞生成的恢复。外周血白细胞计数的恢复先于DNA合成和骨髓细胞数量的增加。IIB回输还促进了以cAMP占主导的淋巴器官细胞数量更快恢复。对所研究过程进行时间上的比较可以推测,IIB的刺激作用与骨髓和淋巴器官中增殖的激活以及细胞成熟的刺激有关。

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