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[紫外线照射血液自体输血后循环白细胞的表面及活化变化]

[Changes in the surface and activation of circulating leukocytes after autologous transfusion of UV-irradiated blood].

作者信息

Samoĭlova K A, Obolenskaia K D, Freĭdlin I S, Gamova I M, Volgareva E V, Nisman B Kh, Runovskaia I V, Mukhuradze N A, Vasiukhin V I

出版信息

Vestn Khir Im I I Grek. 1990 Jun;144(6):99-105.

PMID:2175519
Abstract

Under study was the dynamics of functional properties of leukocytes of healthy people and patients after UV-irradiation of their blood, mixing the UV-irradiated and non-irradiated blood. It was shown that UV-irradiation and mixing the irradiated and non-irradiated blood facilitated the liberation of bactericidal cation proteins of leukocytes, higher expression of membrane receptors, growth factors, activation of reparation of DNA after its injury by gamma-rays. It proves the role of immediate activation of leukocytes of the circulating blood in trigger mechanisms of effects of autotransfusion of UV-irradiated blood.

摘要

本研究针对健康人群以及血液经紫外线照射、紫外线照射血液与未照射血液混合后的患者白细胞功能特性动态变化展开。结果表明,紫外线照射以及照射血液与未照射血液的混合促进了白细胞杀菌阳离子蛋白的释放、膜受体和生长因子的高表达,以及γ射线损伤后DNA修复的激活。这证明了循环血液中白细胞的即时激活在紫外线照射血液自体输血效应触发机制中的作用。

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