Arriagada R, Lê M G, Mouriesse H, Fontaine F, Dewar J, Rochard F, Spielmann M, Lacour J, Tubiana M, Sarrazin D
Institut Gustave-Roussy, Villejuif, France.
Radiother Oncol. 1988 Mar;11(3):213-22. doi: 10.1016/0167-8140(88)90003-5.
A multivariate analysis on 1195 patients with operable breast cancer and histologically positive axillary nodes treated by mastectomy and complete axillary dissection at the Institut Gustave-Roussy between 1958 and 1978 suggests a beneficial effect of treatment of the internal mammary chain (IMC) on the risks of death and distant metastasis for the patients with medial tumors. For these patients, surgical IMC dissection and post-operative irradiation have similar effects on both the risk of death and of distant metastasis. For the patients with lateral tumors, no beneficial effect of the treatment of the IMC on these two risks was observed. Postoperative irradiation to the IMC, axilla, chest wall and supraclavicular nodes significantly decreases the risk of locoregional recurrences independent of the tumor site and surgical management of the lymph nodes.
对1958年至1978年间在古斯塔夫-鲁西研究所接受乳房切除术和腋窝完全清扫术治疗的1195例可手术乳腺癌且腋窝淋巴结组织学检查呈阳性的患者进行的多变量分析表明，对于内侧肿瘤患者，内乳链（IMC）治疗对死亡风险和远处转移风险具有有益作用。对于这些患者，手术IMC清扫和术后放疗对死亡风险和远处转移风险具有相似的效果。对于外侧肿瘤患者，未观察到IMC治疗对这两种风险有有益作用。对IMC、腋窝、胸壁和锁骨上淋巴结进行术后放疗可显著降低局部区域复发风险，而与肿瘤部位和淋巴结的手术处理无关。
