地诺单抗治疗的困境：地诺单抗停药或剂量延迟导致的反弹性骨折 - Suppr

Dilemma of denosumab therapy: rebound fractures with denosumab cessation or dose delay.

作者信息

Herath Madhuni, Wong Phillip, Milat Frances

机构信息

Department of Endocrinology, Monash Health, Melbourne, Victoria, Australia.

Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

出版信息

Intern Med J. 2021 Feb;51(2):297-298. doi: 10.1111/imj.15189.

DOI:10.1111/imj.15189

PMID:33631850

Abstract

摘要

相似文献

Dilemma of denosumab therapy: rebound fractures with denosumab cessation or dose delay.地诺单抗治疗的困境：地诺单抗停药或剂量延迟导致的反弹性骨折

Intern Med J. 2021 Feb;51(2):297-298. doi: 10.1111/imj.15189.

[The denosumab dilemma: to be stopped after 5 years or to be continued in patients with osteoporosis?].[地舒单抗困境：骨质疏松症患者5年后停药还是继续用药？]

Ned Tijdschr Geneeskd. 2018 May 14;162:D2831.

Rebound-associated vertebral fractures after stopping denosumab: Report of four cases.停用地诺单抗后出现的与反弹相关的椎体骨折：4例报告

Joint Bone Spine. 2020 Mar;87(2):171-173. doi: 10.1016/j.jbspin.2019.07.010. Epub 2019 Jul 29.

Effects and management of denosumab discontinuation.地诺单抗停药的影响及管理

Joint Bone Spine. 2018 Oct;85(5):515-517. doi: 10.1016/j.jbspin.2017.12.013. Epub 2018 Jan 6.

Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT).绝经后日本骨质疏松症女性和男性接受三年地诺单抗治疗：地诺单抗骨折干预随机安慰剂对照试验（DIRECT）1年开放标签扩展研究的结果

Osteoporos Int. 2015 Feb;26(2):765-74. doi: 10.1007/s00198-014-2964-2. Epub 2014 Nov 18.

The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study.地诺单抗治疗绝经后骨质疏松症女性8年或5年的效果：FREEDOM扩展研究结果

Osteoporos Int. 2015 Dec;26(12):2773-83. doi: 10.1007/s00198-015-3234-7. Epub 2015 Jul 23.

Stopping Denosumab.停止地舒单抗治疗。

Curr Osteoporos Rep. 2019 Feb;17(1):8-15. doi: 10.1007/s11914-019-00502-4.

[Multiple vertebral fractures after rebound effect of denosumab in postmenopausal woman].[绝经后女性地诺单抗反弹效应后发生多发性椎体骨折]

Aten Primaria. 2024 Feb;56(2):102810. doi: 10.1016/j.aprim.2023.102810. Epub 2023 Nov 15.

Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.地诺单抗停药后发生严重自发性椎体骨折：三例病例报告

Osteoporos Int. 2016 May;27(5):1923-5. doi: 10.1007/s00198-015-3380-y. Epub 2015 Oct 28.

Multiple Rebound-Associated Vertebral Fractures after Denosumab Discontinuation: Is Prompt Antiresorptive Therapy Always Recommended,Even When the Risk of Fracture Seems Low? A Case Report.地舒单抗停药后多发再发相关性椎体骨折：即使骨折风险似乎较低，是否总是推荐立即抗吸收治疗？病例报告。

Endocr Metab Immune Disord Drug Targets. 2021;21(12):2303-2306. doi: 10.2174/1871530321666210708142127.

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Treatment Considerations for Severe Osteoporosis in Older Adults.老年人严重骨质疏松症的治疗考量

Drugs Aging. 2025 May;42(5):395-412. doi: 10.1007/s40266-025-01205-5. Epub 2025 Apr 16.

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Dilemma of denosumab therapy: rebound fractures with denosumab cessation or dose delay.

作者信息

Herath Madhuni, Wong Phillip, Milat Frances

机构信息

Department of Endocrinology, Monash Health, Melbourne, Victoria, Australia.

Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

出版信息

Intern Med J. 2021 Feb;51(2):297-298. doi: 10.1111/imj.15189.

DOI:10.1111/imj.15189

PMID:33631850

Abstract

摘要

Dilemma of denosumab therapy: rebound fractures with denosumab cessation or dose delay.

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Dilemma of denosumab therapy: rebound fractures with denosumab cessation or dose delay.

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