Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Child Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.
Intern Med J. 2021 Feb;51(2):276-279. doi: 10.1111/imj.15191.
During 106 865 person-years of follow up, 17 (1.3%) Fremantle Diabetes Study Phase I participants with Type 2 diabetes and 57 (1.1%) matched individuals without diabetes developed idiopathic pulmonary fibrosis (IPF), an incidence rate ratio (95% confidence interval) of 1.40 (0.76-2.44) (P = 0.22). In the diabetes cohort, age at diabetes diagnosis and total serum cholesterol (inversely) predicted incident IPF in competing risk multivariable models. The incidence of IPF was low in community-based cohorts, regardless of Type 2 diabetes status.
在 106865 人年的随访中，17 名（1.3%）2 型糖尿病的弗里曼特尔糖尿病研究 I 期参与者和 57 名（1.1%）匹配的无糖尿病个体发生了特发性肺纤维化（IPF），发病率比（95%置信区间）为 1.40（0.76-2.44）（P=0.22）。在糖尿病队列中，糖尿病诊断时的年龄和总血清胆固醇（呈负相关）在竞争风险多变量模型中预测了 IPF 的发病。无论 2 型糖尿病状态如何，基于社区的队列中 IPF 的发病率都很低。
