Department of Physical Education, Xihua University, Chengdu, Sichuan, China.
Department of Physical Education, Hubei Minzu University, Enshi, Hubei, China.
PLoS One. 2024 Apr 18;19(4):e0299495. doi: 10.1371/journal.pone.0299495. eCollection 2024.
This study evaluated the effect of 24-week Taichi training and Taichi plus resistance band training on pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus (T2DM). Forty-eight patients with T2DM were randomly divided into three groups: Group A-Taichi training: practiced Taichi 60 min/day, 6 days/week for 24 weeks; Group B-Taichi plus resistance band training: practiced 60-min Taichi 4 days/week plus 60-min resistance band training 2 days/week for 24 weeks; and Group C-controls: maintaining their daily lifestyles. Stepwise multiple regression analysis was applied to predict diffusion capacity of the lungs for carbon monoxide (DLCO) by fasting blood glucose, insulin, glycosylated hemoglobin (HbA1c), tumour necrosis factor alpha (TNF-α), von Willebrand Factor (vWF), interleukin-6 (IL-6), intercellular adhesion molecule 1 (ICAM-1), endothelial nitric oxide synthase (eNOS), nitric oxide (NO), endothelin-1 (ET-1), vascular endothelial growth factor, and prostaglandin I-2. Taichi with or without resistance band training significantly improved DLCO, increased insulin sensitivity, eNOS and NO, and reduced fasting blood glucose, insulin, HbA1c, TNF-α, vWF, IL-6, ICAM-1, and ET-1. There was no change in any of these variables in the control group. DLCO was significantly predicted (R2 = 0.82) by insulin sensitivity (standard-β = 0.415, P<0.001), eNOS (standard-β = 0.128, P = 0.017), TNF-α (standard-β = -0.259, P = 0.001), vWF (standard-β = -0.201, P = 0.007), and IL-6 (standard-β = -0.175, P = 0.032) in patients with T2DM. The impact of insulin sensitivity was the most important predictor for the variation of DLCO based on the multiple regression modeling. This study demonstrates that 24-week Taichi training and Taichi plus resistance band training effectively improve pulmonary diffusion capacity and blood glycemic control in patients with T2DM. Variation of DLCO is explained by improved insulin sensitivity and endothelial function, and reduced inflammatory markers, including TNF-α, vWF, and IL-6.
这项研究评估了 24 周的太极拳训练和太极拳加阻力带训练对 2 型糖尿病（T2DM）患者肺弥散能力和血糖控制的影响。48 名 T2DM 患者被随机分为三组：A 组-太极拳训练：每天练习太极拳 60 分钟，每周 6 天，共 24 周；B 组-太极拳加阻力带训练：每周 4 天练习 60 分钟的太极拳，外加 2 天练习 60 分钟的阻力带训练，共 24 周；C 组-对照组：保持日常的生活方式。逐步多元回归分析用于预测一氧化碳弥散量（DLCO），自变量为空腹血糖、胰岛素、糖化血红蛋白（HbA1c）、肿瘤坏死因子-α（TNF-α）、血管性血友病因子（vWF）、白细胞介素-6（IL-6）、细胞间黏附分子 1（ICAM-1）、内皮型一氧化氮合酶（eNOS）、一氧化氮（NO）、内皮素-1（ET-1）、血管内皮生长因子和前列环素 I-2。太极拳加或不加阻力带训练均可显著改善 DLCO，提高胰岛素敏感性、eNOS 和 NO，降低空腹血糖、胰岛素、HbA1c、TNF-α、vWF、IL-6、ICAM-1 和 ET-1。对照组的这些变量没有任何变化。在 T2DM 患者中，DLCO 显著由胰岛素敏感性（标准β=0.415，P<0.001）、eNOS（标准β=0.128，P=0.017）、TNF-α（标准β=-0.259，P=0.001）、vWF（标准β=-0.201，P=0.007）和 IL-6（标准β=-0.175，P=0.032）预测（R2=0.82）。基于多元回归模型，胰岛素敏感性是 DLCO 变化的最重要预测因子。这项研究表明，24 周的太极拳训练和太极拳加阻力带训练可有效改善 T2DM 患者的肺弥散能力和血糖控制。DLCO 的变化可由胰岛素敏感性提高和内皮功能改善以及炎症标志物（包括 TNF-α、vWF 和 IL-6）减少来解释。
