来自一种栖息于粪便的物种的抗病毒巴弗洛霉素
Antiviral Bafilomycins from a Feces-Inhabiting sp.
作者信息
Xie Xi, Lu Shengsheng, Pan Xiaoyan, Zou Min, Li Fangfang, Lin Haixing, Hu Jianan, Fan Sheng, He Jian
机构信息
Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China.
出版信息
J Nat Prod. 2021 Feb 26;84(2):537-543. doi: 10.1021/acs.jnatprod.0c01243. Epub 2021 Feb 8.
A new bafilomycin derivative () and another seven known bafilomycins (-) were isolated from feces-derived sp. HTL16. The structure of was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
从粪便来源的链霉菌属菌株HTL16中分离出一种新的巴弗洛霉素衍生物（）和另外七种已知的巴弗洛霉素（-）。通过一维和二维核磁共振光谱分析阐明了的结构。生物学测试表明，这些巴弗洛霉素通过抑制内体ATP驱动的质子泵的活性，对甲型流感病毒和SARS-CoV-2病毒表现出强大的抗病毒活性，IC值在纳摩尔范围内。
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