Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea These authors contributed equally to this study.
J Biomater Appl. 2021 Apr;35(9):1109-1118. doi: 10.1177/0885328221995924. Epub 2021 Feb 25.
Monoolein cubic phase immobilizing hydrophobically modified gelatin (HmGel) in its water channel was prepared by a melt-hydration method. The cubic phase was micronized into cubosomes by using hydrophobically modified quaternized cellulose nanofiber (HmQCNF) as a stabilizer. The phase transition temperature of the cubic phase was about 68-70 °C. Small angle X-ray diffraction revealed that HmGel-loaded cubosome stabilized with HmCNF was a diamond type of cubic phase. HmGel-loaded cubosomes stailized with HmQCNF were dependent on the pH value in terms of the release of their payload (i.e, methylene blue) much more strongly than HmGel-loaded cubosomes stabilized with Pluronic F127.
通过熔融水合的方法制备了立方相单油酸甘油酯固定化疏水性改性明胶（HmGel）的水通道。使用疏水性改性季铵化纤维素纳米纤维（HmQCNF）作为稳定剂，将立方相微细化成立方囊泡。立方相的相变温度约为 68-70°C。小角 X 射线衍射表明，用 HmQCNF 稳定的负载 HmGel 的立方囊泡是一种金刚石型立方相。与用 Pluronic F127 稳定的负载 HmGel 的立方囊泡相比，用 HmQCNF 稳定的负载 HmGel 的立方囊泡在释放其有效载荷（即亚甲蓝）方面对 pH 值的依赖性更强。
