Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China.
Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China; Laboratory of Natural Medicine, Wuxi Medical School, Jiangnan University, People's Republic of China.
Mater Sci Eng C Mater Biol Appl. 2017 May 1;74:86-93. doi: 10.1016/j.msec.2017.02.004. Epub 2017 Feb 6.
A simple and cost-effective way to prepare water-stable zein-based nanofibers for potential drug delivery was presented in this article. Corn protein zein was co-electrospun with hydrophobic ethyl cellulose. Indomethacin, as a model drug, was incorporated in situ into the composite nanofibers. Scanning electron microscopy and element mapping revealed the morphologies of drug-loaded nanofibers and drug distribution, respectively. Fourier transform infrared spectra confirmed the physical blending among the components. Differential scanning calorimetry and X-ray diffraction demonstrated the physical state of drug and polymers in the nanofiber matrix. The composite nanofibers showed a sustained diffusion-controlled release according to the results of in vitro dissolution tests.
本文提出了一种简单且经济高效的方法，用于制备用于潜在药物输送的水稳定的玉米醇溶蛋白纳米纤维。玉米醇溶蛋白与疏水性乙基纤维素共电纺丝。将吲哚美辛作为模型药物原位掺入复合纳米纤维中。扫描电子显微镜和元素映射分别揭示了载药纳米纤维的形态和药物分布。傅里叶变换红外光谱证实了各组分之间的物理共混。差示扫描量热法和 X 射线衍射表明了药物和聚合物在纳米纤维基质中的物理状态。根据体外溶解试验的结果，复合纳米纤维表现出持续的扩散控制释放。
