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成人先天性心脏病的神经系统并发症。

Neurologic complications of congenital heart disease in adults.

机构信息

Department of Medicine, Division of Cardiology, Duke University, Durham, NC, United States.

Department of Neurology, Kentucky Neuroscience Institute, University of Kentucky, Lexington, KY, United States.

出版信息

Handb Clin Neurol. 2021;177:15-22. doi: 10.1016/B978-0-12-819814-8.00011-1.

Abstract

Congenital heart disease (CHD) is a heterogeneous group of structural abnormalities of the cardiovascular system that are present at birth. Advances in childhood medical and surgical treatment have led to increasing numbers of adults with CHD. Neurological complications of CHD in adults are varied and can include an increased risk of stroke not only related to the underlying congenital defect and its surgical management but also due to atherosclerotic disease associated with advancing age. In addition to cerebrovascular events, CHD in adults is also associated with an increased risk of neurodevelopmental disorders, cognitive impairment, psychiatric disease, and epilepsy. Collaborative multidisciplinary care with contributions from neurologists and cardiologists with expertise in adult CHD is necessary to provide optimal long-term care for this complex and rapidly evolving population.

摘要

先天性心脏病(CHD)是一组出生时即存在的心血管系统结构异常的异质性疾病。儿童医学和外科治疗的进步导致患有 CHD 的成年人数量不断增加。成人 CHD 的神经系统并发症多种多样,不仅与潜在的先天性缺陷及其手术治疗有关,而且还与与年龄相关的动脉粥样硬化疾病有关,可导致中风风险增加。除了脑血管事件外,成人 CHD 还与神经发育障碍、认知障碍、精神疾病和癫痫的风险增加有关。需要神经科医生和心脏病专家的多学科协作,为这一复杂且快速发展的人群提供最佳的长期护理。

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