Division of Neurology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.
Division of Neurology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.
Handb Clin Neurol. 2021;177:1-13. doi: 10.1016/B978-0-12-819814-8.00010-X.
Improved medical management and surgical outcomes have significantly decreased mortality in children with congenital heart disease; however, with increased survival, there is a greater lifetime exposure to neurologic complications with serious long-term neurodevelopmental consequences. Thus, recent focus has shifted to recognition and reduction of these extracardiac comorbidities. Vascular and infective complications, such as arterial ischemic stroke, infective endocarditis, and localization-related epilepsy are some of the most common neurologic comorbidities of congenital heart disease. In addition, it is now well recognized that congenital heart disease has an impact on overall brain development and contributes to adverse neurodevelopmental outcomes across multiple domains. The goal of this chapter is to summarize the most common neurologic comorbidities of congenital heart disease and its management.
医学管理的改善和外科手术效果的提升显著降低了患有先天性心脏病的儿童的死亡率;然而,随着存活率的提高,患儿终生暴露于神经并发症的风险增加,这会导致严重的长期神经发育后果。因此,最近的重点已经转移到识别和减少这些心脏外合并症上。血管和感染并发症,如动脉缺血性脑卒中、感染性心内膜炎和与定位相关的癫痫,是先天性心脏病最常见的神经合并症之一。此外,现在人们已经认识到先天性心脏病会影响大脑的整体发育,并导致多个领域的不良神经发育结果。本章的目标是总结先天性心脏病的常见神经合并症及其管理。