Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Med Clin (Barc). 2021 Jun 11;156(11):547-554. doi: 10.1016/j.medcli.2020.12.017. Epub 2021 Jan 28.
Since the World Health Organization (WHO) announced coronavirus disease 2019 (COVID-19) had become a global pandemic on March 11, 2020, the number of infections has been increasing. The purpose of this meta-analysis was to investigate the prognosis of COVID-19 in patients with coronary heart disease.
Pubmed, Embase, and Cochrane Library databases were searched to collect the literature concerning coronary heart disease and COVID-19. The retrieval time was from inception to Nov 20, 2020, using Stata version 14.0 for meta-analysis.
A total of 22,148 patients from 40 studies were included. The meta-analysis revealed that coronary heart disease was associated with poor prognosis of COVID-19 (OR=3.42, 95%CI [2.83, 4.13], P<0.001). After subgroup analysis, coronary heart disease was found to be related to mortality (OR=3.75, 95%CI [2.91, 4.82], P<0.001), severe/critical COVID-19 (OR=3.23, 95%CI [2.19, 4.77], P<0.001), ICU admission (OR=2.25, 95%CI [1.34, 3.79], P=0.002), disease progression (OR=3.01, 95%CI [1.46, 6.22], P=0.003); Meta-regression showed that the association between coronary heart disease and poor prognosis of COVID-19 was affected by hypertension (P=0.004), and subgroup analysis showed that compared with the proportion of hypertension >30% (OR=2.85, 95%CI [2.33, 3.49]), the proportion of hypertension <30% (OR=4.78, 95%CI [3.50, 6.51]) had a higher risk of poor prognosis.
Coronary heart disease is a risk factor for poor prognosis in patients with COVID-19.
自 2020 年 3 月 11 日世界卫生组织（WHO）宣布 2019 年冠状病毒病（COVID-19）成为全球大流行以来，感染人数一直在增加。本荟萃分析的目的是探讨冠心病患者 COVID-19 的预后。
检索 Pubmed、Embase 和 Cochrane Library 数据库，收集有关冠心病和 COVID-19 的文献。检索时间为从成立到 2020 年 11 月 20 日，使用 Stata 版本 14.0 进行荟萃分析。
共有来自 40 项研究的 22148 名患者纳入分析。荟萃分析显示，冠心病与 COVID-19 的不良预后相关（OR=3.42，95%CI [2.83, 4.13]，P<0.001）。亚组分析后发现，冠心病与死亡率（OR=3.75，95%CI [2.91, 4.82]，P<0.001）、重症/危重症 COVID-19（OR=3.23，95%CI [2.19, 4.77]，P<0.001）、重症监护病房（ICU）入院（OR=2.25，95%CI [1.34, 3.79]，P=0.002）、疾病进展（OR=3.01，95%CI [1.46, 6.22]，P=0.003）相关。Meta 回归显示，冠心病与 COVID-19 不良预后的相关性受高血压影响（P=0.004），亚组分析显示，与高血压比例>30%（OR=2.85，95%CI [2.33, 3.49]）相比，高血压比例<30%（OR=4.78，95%CI [3.50, 6.51]）不良预后的风险更高。
冠心病是 COVID-19 患者不良预后的危险因素。
