Tuomi T, Aho K, Palosuo T, Kaarela K, von Essen R, Isomäki H, Leirisalo-Repo M, Sarna S
National Public Health Institute, Helsinki, Finland.
Rheumatol Int. 1988;8(1):21-6. doi: 10.1007/BF00541346.
A community-based cohort comprising 150 patients with recent-onset seropositive arthritis or seronegative oligoarthritis or polyarthritis was monitored for 8 years. Of the different rheumatoid factor (RF) tests, the initial positivity in the most sensitive assays (latex slide test and IgM-RF by enzyme immunoassay) was the most reliable factor when distinguishing between the erosive and nonerosive cases. The individual RF isotypes fluctuated in four serial specimens, but each patient tended to preserve his or her reactivity pattern. Seroconversion from positive to negative within the 1st year of follow-up did not indicate a particularly good long-term prognosis.
对一个由150例近期发病的血清阳性关节炎或血清阴性寡关节炎或多关节炎患者组成的社区队列进行了8年的监测。在不同的类风湿因子（RF）检测中，最敏感检测方法（乳胶玻片试验和酶免疫法检测IgM-RF）的初始阳性是区分侵蚀性和非侵蚀性病例时最可靠的因素。个体RF同种型在四个连续样本中波动，但每位患者倾向于保持其反应模式。随访第1年内血清学由阳性转为阴性并不表明长期预后特别良好。
