早期类风湿性关节炎的前瞻性研究。I. IgA类风湿因子的预后价值。
Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor.
作者信息
Teitsson I, Withrington R H, Seifert M H, Valdimarsson H
出版信息
Ann Rheum Dis. 1984 Oct;43(5):673-8. doi: 10.1136/ard.43.5.673.
Abstract
Thirty-three patients with early arthritis, 28 of whom developed classical/definite rheumatoid arthritis (RA), were followed up for two to four years. Rheumatoid factor (RF) levels of the IgM, IgA, and IgG isotypes were measured in serum and synovial fluid by an ELISA technique developed in our laboratory. All seven patients who presented with raised IgA RF developed erosions of their hands and wrists. This was significantly different from the remaining 26. By contrast none of the five patients who presented with isolated elevation of IgM RF developed erosive disease. The patients with raised IgA RF needed significantly more treatment with 'specific' drugs than the remaining 26. It is suggested that the detection of IgA RF in early RA indicates poor prognosis, justifying a more aggressive treatment at an early stage.
摘要
33例早期关节炎患者，其中28例发展为典型/确诊类风湿关节炎（RA），随访2至4年。采用我们实验室开发的ELISA技术检测血清和滑液中IgM、IgA和IgG同种型类风湿因子（RF）水平。所有7例IgA RF升高的患者均出现手部和腕部侵蚀。这与其余26例有显著差异。相比之下，5例仅IgM RF升高的患者均未发生侵蚀性疾病。IgA RF升高的患者比其余26例患者需要显著更多的“特异性”药物治疗。提示早期RA中IgA RF的检测表明预后不良，证明早期应采取更积极的治疗。
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本文引用的文献
1
COURSE AND PROGNOSIS IN RHEUMATOID ARTHRITIS. A FURTHER REPORT.类风湿关节炎的病程与预后。进一步报告。
Ann Rheum Dis. 1964 May;23(3):193-204. doi: 10.1136/ard.23.3.193.
2
REACTION OF 7S AND 19S COMPONENTS OF IMMUNE RABBIT ANTISERA WITH HUMAN GROUP A AND AB RED CELLS.免疫兔抗血清的7S和19S成分与人A组及AB型红细胞的反应
Immunology. 1963 Sep;6(5):421-33.
3
Significance of the Waaler-Rose test, streptococcal agagglutination, and antistreptolysin titre in the prognosis of rheumatoid arthritis.瓦勒-罗斯试验、链球菌凝集反应及抗链球菌溶血素效价在类风湿关节炎预后中的意义
Ann Rheum Dis. 1959 Mar;18(1):24-8. doi: 10.1136/ard.18.1.24.
4
Analysis of immune complexes in synovial effusions of patients with rheumatoid arthritis.类风湿关节炎患者滑膜积液中免疫复合物的分析。
Clin Exp Immunol. 1980 Feb;39(2):297-306.
5
Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis.耶尔森菌关节炎中针对耶尔森菌的 IgM、IgG 和 IgA 抗体的持续存在情况。
J Infect Dis. 1980 Apr;141(4):424-9. doi: 10.1093/infdis/141.4.424.
6
Incidence and specificities of IgA and IgM anti-AgG autoantibodies in various mouse strains and colonies.不同小鼠品系和群体中IgA和IgM抗AgG自身抗体的发生率及特异性。
J Exp Med. 1980 Jan 1;151(1):45-55. doi: 10.1084/jem.151.1.45.
7
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8
Autoimmune hemolytic anemia with predominance of IgA autoantibody.以IgA自身抗体为主的自身免疫性溶血性贫血。
Transfusion. 1982 May-Jun;22(3):238-40. doi: 10.1046/j.1537-2995.1982.22382224949.x.
9
10
Pathogenic role of a monoclonal IgA (kappa ) anti-IgG paraprotein associated with hemorrhagic diathesis, rheumatoid arthritis, vascular purpura, and acute membranoproliferative glomerulonephritis.一种与出血素质、类风湿性关节炎、血管性紫癜及急性膜增生性肾小球肾炎相关的单克隆IgA（κ）抗IgG副蛋白的致病作用
J Clin Immunol. 1982 Apr;2(2):75-85. doi: 10.1007/BF00916890.
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